Results 71 to 80 of about 8,266,387 (310)
Nature Communications, 2021 Intratumoral immunotherapy is an emerging modality for the treatment of solid tumors. Toll-like receptor (TLR) agonists have shown promise for eliciting immune responses, but systemic administration often results in the development of adverse side ...
B. Bahmani +11 more
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Modelling of Tirapazamine effects on solid tumour morphology [PDF]
, 2011 Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive ...
Kazmi, Nabila +5 more
core +1 more source
Radon risk mapping in Spain: a population and building-inclusive approach
Environment InternationalRadon is a major health risk and a leading cause of lung cancer among non-smokers. Traditional radon maps in Spain, such as those from the Consejo de Seguridad Nuclear (CSN), rely primarily on geological data but do not account for building ...
Miquel Ferriol-Galmés +11 more
doaj +1 more source
International Journal of Molecular SciencesHypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an important role in cellular reprogramming processes under hypoxic conditions, which facilitate solid tumors’ progression.
A. G. Magar +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The interplay between stress and growth in solid tumors [PDF]
, 2012 A number of biological phenomena are interlaced with classical mechanics. In this review we discuss the role of mechanics in tumor growth, namely the avascular phase of solid tumors.
Ambrosi, Davide Carlo +4 more
core +1 more source
Gastroenterology Research and Practice, 2015 Pancreatic cancer is one of the most fatal malignancies with increasing incidence and high mortality. Possibilities for early diagnosis are limited and there is currently no efficient therapy.
Tereza Halkova +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Journal of Experimental & Clinical Cancer ResearchBackground Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and a poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin ...
Daniel Oyon +27 more
doaj +1 more source