Results 51 to 60 of about 90,786 (303)

Process Optimization, Microstructure and Mechanical Properties of SiC + TiB₂/AlSi10Mg Composites Fabricated by Laser-Directed Energy Deposition

Journal of Manufacturing and Materials Processing
In this study, TiB2/AlSi10Mg, 2 wt.% SiC + TiB2/AlSi10Mg, and 5 wt.% SiC + TiB2/AlSi10Mg composite powders were prepared via high-energy ball milling.
Xin Zhang, Siyu Zhang, Yijie Peng, Long Geng, Chennuo Kang, Zhe Feng, Wei Fan, Hua Tan, Xin Lin   +8 more
doaj   +1 more source

Assessment of the effect of 3D printed sand mold thickness on solidification process of AlSi13 casting alloy [PDF]

, 2021
The present work addresses the printed sand mold thickness effect on the solidification process of a eutectic aluminum-silicon alloy (AlSi13). Several sandmold thicknesses (varying from 3 to 30mm) are numerically studied using Quikcast®software.
EL MANSOURI, Mohamed, BEN SAADA, Mariem
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Segregation-dislocation self-organized structures ductilize a work-hardened medium entropy alloy

Nature Communications
Dislocations are the intrinsic origin of crystal plasticity. However, initial high-density dislocations in work-hardened materials are commonly asserted to be detrimental to ductility according to textbook strengthening theory.
Bojing Guo, Dingcong Cui, Qingfeng Wu, Yuemin Ma, Daixiu Wei, Kumara L. S. R, Yashan Zhang, Chenbo Xu, Zhijun Wang, Junjie Li, Xin Lin, Jincheng Wang, Xun-li Wang, Feng He   +13 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Effects of microstructure on high cycle fatigue properties of dual-phase Ti alloy: combined nonlocal CPFE simulations and extreme value statistics

Journal of Materials Research and Technology, 2020
The nonlocal crystal plasticity finite element (CPFE) simulations and extreme value statistics were combined to study the effects of microstructure on the high cycle fatigue (HCF) behavior of dual-phase Ti alloy.
Mengqi Zhang, Fengbo Han, Bin Tang, Hongchao Kou, Jiangkun Fan, Jinshan Li   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Real-Time Method to Detect the Deformation Behavior during Laser Solid Forming of Thin-Wall Structure

Metals, 2020
Laser solid forming (LSF) is a promising additive manufacturing technology. In the LSF process, deformation behaviors dictate the accuracy of the produced parts. In this study, by using a laser displacement detector based on laser triangulation principle,
Hua Tan, Yuguang Chen, Zhe Feng, Wei Hou, Wei Fan, Xin Lin   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source