Results 71 to 80 of about 108,716 (266)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Study on the Correlation Between Solidification-Solution Treatment Microstructure and Process Parameters of Superalloy via Integrated Multi-Component Phase-Field Simulation

Engineered Science
Nickel-based single-crystal superalloys demonstrate remarkable mechanical properties at elevated temperatures. Solidification and solution treatment are critical steps in determining the properties.
Tingting Cui, Min Yang, Li Wan, Xin Wang, Xinbing Zhang, Min Guo, Haijun Su   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Grain refinement in a AlZnMgCuTi alloy by intensive melt shearing: A multi-step nucleation mechanism [PDF]

, 2011
This is a post-print version of the article. Copyright @ 2010 Elsevier B.V.Direct chill (DC) cast ingots of wrought Al alloys conventionally require the deliberate addition of a grain refiner to provide a uniform as-cast microstructure for the ...
Jarry, P, Li, HT, Scamans, GM, G.M. Scamans, Xia, M, H.T. Li, M. Xia, Z. Fan, Fan, Z, Ph. Jarry   +9 more
core   +1 more source

Crystal plasticity modeling of deformation behavior of Al–Al2Cu eutectics based on high-fidelity representative microstructures

Journal of Materials Research and Technology
A comprehensive understanding of material deformation behavior holds importance in enhancing the properties of materials, which can be achieved through modeling the relationship between microstructure and deformation behavior by an appropriate crystal ...
Meirong Jiang, Yiming Chen, Zhongsheng Yang, Xiaobing Hu, Lei Zhang, Junjie Li, Zhijun Wang, Shuangming Li, Jincheng Wang   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Insight of the dendrite's deformation and fracture in large-sized single-crystal superalloy blades for the formation of slivers

Journal of Materials Research and Technology
The manufacturing of single-crystal superalloy blades consistently aims to avoid grain boundary defects that compromise crystal integrity. Although slivers represent a significant type of grain boundary defect, their formation mechanisms remain ...
Chao Zhang, Taiwen Huang, Hanyuan Xu, Yari Cai, Yuhan Zhou, Haitao Fu, Qian Huang, Jun Zhang, Lin Liu   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multiple deformation mechanisms induce high work hardening in Ti–5Al–7.5 V alloy via transformed β matrix

Materials Research Letters
In this work, different transformed β matrix was obtained in Ti–5Al–7.5 V alloy. The alloy with equiaxed αp phase and transformed β matrix containing α′ martensite and β phase exhibits good combination of strength and plasticity, as well as a high work ...
Sisi Xie, Zhihong Wu, Nana Chen, Mingxiang Zhu, Hao Yang, Zilong Zhang, Chuanyun Wang, Jinshan Li, Hongchao Kou   +8 more
doaj   +1 more source