Results 71 to 80 of about 90,786 (303)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Metastable microstructure evolution and grain refinement in a Low-Ta containing γ-TiAl alloy through heat treatment

Journal of Materials Research and Technology
The paper comprehensively describes the evolution of metastable microstructures in a cast low-Ta-containing γ-TiAl alloy during cooling-tempering-lamellarization heat treatments. The behavior and mechanism of microstructure refinement are discussed.
Zitong Gao, Rui Hu, Hang Zou, Jinguang Li, Mi Zhou, Xian Luo   +5 more
doaj   +1 more source

Modelling of the binary alloy solidification process

, 1992
Bibliography: leaves 129-132.A thermodynamically consistent model capable of modelling a binary alloy undergoing solidification or melting is developed. The theory is continuum based, and the solid-liquid phase change system is described macroscopically ...
McAdie, R L
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Growth of potassium tantalate (KTaO3) crystals by directional solidification [PDF]

, 2013
Potassium tantalate (KTaO3) crystals were grown by directional solidification from various compositions of K2CO3-Ta2O5 melt. When raw materials with the stoichiometric composition (K2CO3:Ta2O5=50:50 mol%) were used, K6Ta10.8O30 crystallized as the ...
Takenaka, Takayuki, Bamba, Noriko, Taishi, Toshinori, Hoshikawa, Keigo, Hosokawa, Kazuya   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research progress in microstructure，defects and mechanical properties of IN718 superalloy thin wall fabricated by laser powder bed fusion

Journal of Aeronautical Materials
IN718 superalloy is extensively utilized in the aerospace and nuclear industries due to its outstanding oxidation resistance，heat-corrosion resistance，good structural stability，fatigue performance and safety reliability.
YANG Peixin, SU Haijun, GUO Yinuo, HUO Chuanteng, ZHOU Wenbo, HE Mingdie, YANG Wenchao, LIU Lin   +7 more
doaj   +1 more source

The Effect of Thermal Cycling Treatments on the Thermal Stability and Mechanical Properties of a Ti-Based Bulk Metallic Glass Composite

Metals, 2016
The effect of thermal cycling treatments on the thermal stability and mechanical properties of a Ti48Zr20Nb12Cu5Be15 bulk metallic glass composite (BMGC) has been investigated.
Fan Bu, Jun Wang, Liyuan Li, Hongchao Kou, Xiangyi Xue, Jinshan Li   +5 more
doaj   +1 more source

Solidification behaviour and mechanical properties of cast Mg-alloys and Al-based particulate metal matrix composites under intensive shearing

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Magnesium alloys, as the lightest of all structural metallic materials, and aluminium-based particulate metal matrix composites (PMMCs), offering unified ...
Tzamtzis, Spyridon
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source