Results 91 to 100 of about 201,266 (295)

Phase field simulation of dendritic microstructure in additively manufactured titanium alloy [PDF]

, 2019
Additive manufacturing (AM) processes for metals, such as selective laser sintering and electron beam melting, involve rapid solidification process. The microstructure of the fabricated material and its properties strongly depend on the solidification ...
Meng, Lingbin, Wu, Linmin, Zhang, Jing, Zhang, Yi   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Strong magnetic field effect on the nucleation of a highly undercooled Co-Sn melt

Scientific Reports, 2017
High magnetic field is a powerful tool to tune the microstructure and improve the properties of materials. In this report, the nucleation behavior of undercooled Co76Sn24 near eutectic alloy under strong homogeneous and gradient magnetic fields have been
Jun Wang, Yixuan He, Jinshan Li, Hongchao Kou, Eric Beaugnon   +4 more
doaj   +1 more source

Studies of convection in a solidifying binary mixture at reduced gravity [PDF]

A great deal of interest was generated recently in the possibility of producing new materials in the reduced gravity environment provided during the forthcoming missions of Spacelab.
Antar, B. N., Collins, F.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Multiple deformation mechanisms induce high work hardening in Ti–5Al–7.5 V alloy via transformed β matrix

Materials Research Letters
In this work, different transformed β matrix was obtained in Ti–5Al–7.5 V alloy. The alloy with equiaxed αp phase and transformed β matrix containing α′ martensite and β phase exhibits good combination of strength and plasticity, as well as a high work ...
Sisi Xie, Zhihong Wu, Nana Chen, Mingxiang Zhu, Hao Yang, Zilong Zhang, Chuanyun Wang, Jinshan Li, Hongchao Kou   +8 more
doaj   +1 more source

The role of gravity on macrosegregation in alloys [PDF]

During dendritic solidification liquid flow is induced both by buoyancy forces and solidification shrinkage. There is strong evidence that the major reason for the liquid flow is the former, i.e., thermosolutal convection. In the microgravity environment,
Chen, C. F., Heinrich, J. C., Poirier, D. R.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Insight of the dendrite's deformation and fracture in large-sized single-crystal superalloy blades for the formation of slivers

Journal of Materials Research and Technology
The manufacturing of single-crystal superalloy blades consistently aims to avoid grain boundary defects that compromise crystal integrity. Although slivers represent a significant type of grain boundary defect, their formation mechanisms remain ...
Chao Zhang, Taiwen Huang, Hanyuan Xu, Yari Cai, Yuhan Zhou, Haitao Fu, Qian Huang, Jun Zhang, Lin Liu   +8 more
doaj   +1 more source