Results 91 to 100 of about 90,786 (303)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Research progress on formation and suppression of crack defects in oxide eutectic ceramics by laser additive manufacturing

Cailiao gongcheng
Oxide eutectic ceramics have excellent high specific strength, high temperature resistance, corrosion resistance, oxidation and creep resistance, and so on, which are considered to be the promising materials to be used in ultra-high temperature oxidation,
YAO Jiatong, SU Haijun, JIANG Hao, CHEN Qian, SHEN Zhonglin, YU Minghui, ZHANG Zhuo, GUO Min   +7 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Inferring the development of microsegregation and microstructure in Spheroidal and Compacted Graphite Iron using EPMA‐WDS

, 2017
Microsegregation is closely related to the solidification characteristics and microstructure development of a material. In this paper, the microsegregation of Si, Cu, Mn, and P was investigated on a spheroidal and a compacted graphite iron using a ...
Diószegi, Attila, Domeij, Björn
core  

Validated thermodynamic prediction of AlP and eutectic (Si) solidification sequence in Al-Si cast alloys [PDF]

, 2016
The eutectic microstructure in hypoeutectic Al-Si cast alloys is strongly influenced by AlP particles which are potent nuclei for the eutectic (Si) phase. The solidification sequence of AlP and (Si) phases is, thus, crucial for the nucleation of eutectic
Schmid-Fetzer, Rainer, Liang, Song-Mao
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Insight of the dendrite's deformation and fracture in large-sized single-crystal superalloy blades for the formation of slivers

Journal of Materials Research and Technology
The manufacturing of single-crystal superalloy blades consistently aims to avoid grain boundary defects that compromise crystal integrity. Although slivers represent a significant type of grain boundary defect, their formation mechanisms remain ...
Chao Zhang, Taiwen Huang, Hanyuan Xu, Yari Cai, Yuhan Zhou, Haitao Fu, Qian Huang, Jun Zhang, Lin Liu   +8 more
doaj   +1 more source

Phase-field approach to polycrystalline solidification including heterogeneous and homogeneous nucleation

, 2008
Advanced phase-field techniques have been applied to address various aspects of polycrystalline solidification including different modes of crystal nucleation.
Granasy, L, Pusztai, T, Tegze, G, Környei, L, Tóth, G, Bansel, G, Fan, Z   +6 more
core  

Objects Interacting with Solidification Fronts: Thermal and Solute Effects

, 2020
In many materials processing routes, objects such as bubbles or particles interact with a moving solidification front. The output of this confrontation, from instantaneous encapsulation to complete rejection of objects, regulates the solidified ...
Sidhanth, Tyagi, Hélène, Huynh, Cécile, Monteux, Sylvain, Deville   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source