Results 101 to 110 of about 90,786 (303)

Formation and suppression of cracks in ceramics prepared directly by laser additive manufacturing

Cailiao gongcheng
Ceramic materials， with their high strength， high hardness， excellent high-temperature resistance， and superior corrosion resistance， have broad application prospects in fields such as machinery， electronics， aerospace， and biomedical engineering ...
YU Minghui, SU Haijun, SHEN Zhonglin, JIANG Hao, YANG Peixin, ZHANG Zhuo, GUO Min   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Enhanced laser printability and strength-ductility synergy in oxide dispersion strengthened (ODS) GH3536 superalloy manufactured by laser powder-bed fusion

Materials & Design
Additively manufactured oxide dispersion strengthened (ODS) Ni-based superalloy exhibits superior mechanical properties and exceptional oxidation resistance, demonstrating significant potential for applications in high-temperature environments.
Yinuo Guo, Haijun Su, Le Xia, Peixin Yang, Quandong Hu, Mingdie He, Yihe Zhang, Wenchao Yang, Min Yang, Taiwen Huang   +9 more
doaj   +1 more source

Experimental Studies of Gray Cast Iron Solidification with Linear Variable Differential Transformer

, 2015
Expansion during the solidification of gray cast iron was studied by the help of Linear Variable Differential Transformer (LVDT). The chemical composition of the samples was altered by adding two types of inoculant; Superseed® (50% Si, 1% Sr and 0.5% Al)
Tadesse, Abel,, Hasse Fredriksson, Fredriksson, Hasse,, Abel Tadesse   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Dimensionality-tailored pure organic semiconductor with high hole mobility for low-dose x-ray imaging

Nature Communications
Pure-organic semiconductors have attracted broad interest in tissue-equivalent and biocompatible X-ray sensors, while their low-dose X-ray imaging capability still suffers from poor charge transport properties.
Jiahao Geng, Donghao Ma, Meng Xu, Zhihui Gao, Long Zhou, Zixuan Jia, Mengyao Liu, Zhiyu Zheng, Wei Zheng, Huaiyu Zhang, Xinkai Peng, Chen Li, Dou Zhao, Wanqi Jie, Yadong Xu   +14 more
doaj   +1 more source

On the Solidification of Metal Alloys during Microgravity Conditions

, 2015
Thermal analysis and unidirectional solidification experiments of mainly Al-, Sn- and Pb-base alloys has been performed during Rocket Flights, Parabolic aircraft flights, Space Lab, and GAS-Shuttle flights over three decades.
Hasse Fredriksson, Fredriksson, Hasse,
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Numerical And Experimental Analysis Of Macrosegregation During Upward And Downward Solidification Of A Ternary Al-cu-si Alloy

, 2015
In this article macrosegregation phenomena in ternary Al-Cu-Si alloys are investigated by a numerical modeling technique and by upward and downward unidirectional solidification experiments.
Nestler B., Spinelli J.E., Ferreira I.L., Garcia A.   +3 more
core