Results 81 to 90 of about 108,716 (266)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mechanisms of grain refinement by intensive shearing of AZ91 alloy melt [PDF]

, 2010
The official published version of the article can be accessed at the link below.It has been demonstrated recently that intensive melt shearing can be an effective approach to the grain refinement of both shape casting and continuous casting of Mg alloys.
H. Men, Men, H, Jiang, B, B. Jiang, Z. Fan, Fan, Z   +5 more
core   +1 more source

Formation and suppression of cracks in ceramics prepared directly by laser additive manufacturing

Cailiao gongcheng
Ceramic materials， with their high strength， high hardness， excellent high-temperature resistance， and superior corrosion resistance， have broad application prospects in fields such as machinery， electronics， aerospace， and biomedical engineering ...
YU Minghui, SU Haijun, SHEN Zhonglin, JIANG Hao, YANG Peixin, ZHANG Zhuo, GUO Min   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Research progress on formation and suppression of crack defects in oxide eutectic ceramics by laser additive manufacturing

Cailiao gongcheng
Oxide eutectic ceramics have excellent high specific strength, high temperature resistance, corrosion resistance, oxidation and creep resistance, and so on, which are considered to be the promising materials to be used in ultra-high temperature oxidation,
YAO Jiatong, SU Haijun, JIANG Hao, CHEN Qian, SHEN Zhonglin, YU Minghui, ZHANG Zhuo, GUO Min   +7 more
doaj   +1 more source

A Solidification Model for Atomization

ISIJ International, 2009
A microsegregation solidification model has been extended for an individual droplet falling through a stagnant gas during the atomization process. Assuming a uniform temperature within the droplet, the model takes into account nucleation undercooling and equiaxed growth of the dendritic and eutectic microstruc-tures until complete solidification.1 It ...
Prasad, Arvind, Mosbah, Salem, Henein, Hani, Gandin, Charles-André   +3 more
openaire   +5 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Strong magnetic field effect on the nucleation of a highly undercooled Co-Sn melt

Scientific Reports, 2017
High magnetic field is a powerful tool to tune the microstructure and improve the properties of materials. In this report, the nucleation behavior of undercooled Co76Sn24 near eutectic alloy under strong homogeneous and gradient magnetic fields have been
Jun Wang, Yixuan He, Jinshan Li, Hongchao Kou, Eric Beaugnon   +4 more
doaj   +1 more source