Results 81 to 90 of about 113,242 (268)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Study on the Correlation Between Solidification-Solution Treatment Microstructure and Process Parameters of Superalloy via Integrated Multi-Component Phase-Field Simulation

Engineered Science
Nickel-based single-crystal superalloys demonstrate remarkable mechanical properties at elevated temperatures. Solidification and solution treatment are critical steps in determining the properties.
Tingting Cui, Min Yang, Li Wan, Xin Wang, Xinbing Zhang, Min Guo, Haijun Su   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effect of melt flow on dendritic growth in AlSi7-based alloys during directional solidification

, 2022
S.335-338High-strength automotive components are often made of AlSi7-based alloys. A very challenging problem with aluminium casting is the influence of melt flow during solidification, because it affects the microstructure formation and therefore the ...
Dagner, J., Sturz, L., Zimmermann, G., Walterfang, M.   +3 more
core   +1 more source

Formation and suppression of cracks in ceramics prepared directly by laser additive manufacturing

Cailiao gongcheng
Ceramic materials， with their high strength， high hardness， excellent high-temperature resistance， and superior corrosion resistance， have broad application prospects in fields such as machinery， electronics， aerospace， and biomedical engineering ...
YU Minghui, SU Haijun, SHEN Zhonglin, JIANG Hao, YANG Peixin, ZHANG Zhuo, GUO Min   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Crystal plasticity modeling of deformation behavior of Al–Al2Cu eutectics based on high-fidelity representative microstructures

Journal of Materials Research and Technology
A comprehensive understanding of material deformation behavior holds importance in enhancing the properties of materials, which can be achieved through modeling the relationship between microstructure and deformation behavior by an appropriate crystal ...
Meirong Jiang, Yiming Chen, Zhongsheng Yang, Xiaobing Hu, Lei Zhang, Junjie Li, Zhijun Wang, Shuangming Li, Jincheng Wang   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Phase Transformation Kinetics of a FCC Al_0.25CoCrFeNi High-Entropy Alloy during Isochronal Heating

Metals, 2018
The phase transformation kinetics of a face-centered-cubic (FCC) Al0.25CoCrFeNi high-entropy alloy during isochronal heating is investigated by thermal dilation experiment.
Jun Wang, Chen Wei, Haoxue Yang, Tong Guo, Tingting Xu, Jinshan Li   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source