Results 81 to 90 of about 90,786 (303)

Crystal plasticity modeling of deformation behavior of Al–Al2Cu eutectics based on high-fidelity representative microstructures

Journal of Materials Research and Technology
A comprehensive understanding of material deformation behavior holds importance in enhancing the properties of materials, which can be achieved through modeling the relationship between microstructure and deformation behavior by an appropriate crystal ...
Meirong Jiang, Yiming Chen, Zhongsheng Yang, Xiaobing Hu, Lei Zhang, Junjie Li, Zhijun Wang, Shuangming Li, Jincheng Wang   +8 more
doaj   +1 more source

Melt conditioning by advanced shear technology (MCAST) for refining solidification microstructures

, 2009
MCAST (melt conditioning by advanced shear technology) is a novel processing technology developed recently by BCAST at Brunel University for conditioning liquid metal prior to solidification processing.
Patel, JB, Li, HT, Scamans, GM, Bian, Z, Wang, Y, Bayandorian, I, Liu, G, Xia, M, Zhang, H, Fan, Z   +9 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multiple deformation mechanisms induce high work hardening in Ti–5Al–7.5 V alloy via transformed β matrix

Materials Research Letters
In this work, different transformed β matrix was obtained in Ti–5Al–7.5 V alloy. The alloy with equiaxed αp phase and transformed β matrix containing α′ martensite and β phase exhibits good combination of strength and plasticity, as well as a high work ...
Sisi Xie, Zhihong Wu, Nana Chen, Mingxiang Zhu, Hao Yang, Zilong Zhang, Chuanyun Wang, Jinshan Li, Hongchao Kou   +8 more
doaj   +1 more source

Strong magnetic field effect on the nucleation of a highly undercooled Co-Sn melt

Scientific Reports, 2017
High magnetic field is a powerful tool to tune the microstructure and improve the properties of materials. In this report, the nucleation behavior of undercooled Co76Sn24 near eutectic alloy under strong homogeneous and gradient magnetic fields have been
Jun Wang, Yixuan He, Jinshan Li, Hongchao Kou, Eric Beaugnon   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Magnesium alloy strip produced by a melt-conditioned twin roll casting process

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Twin roll casting (TRC) offers a promising route for the economic production of Mg sheet, but unfortunately, it produces strip with coarse and non-uniform
Bayandorian, Iman
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modeling of primary dendrite arm spacing variations in thin-slab casting of low carbon and low alloy steels

, 2012
Solidification structure of a High Strength Low Alloy (HSLA) steel, in terms of dendrite arm spacing distribution across the shell thickness, is studied in a breakout shell from a thin-slab caster at Tata Steel in IJmuiden.
Boom, R, Abbel, G, Mehrara, H, Santillana, B, Eskin, DG, Katgerman, L   +5 more
core   +1 more source