Results 81 to 90 of about 17,105 (305)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

How solid is solidity? An in-dept study of solidity’s type safety. [PDF]

, 2022
Blockchain has evolved a lot in the last years: one of the most important features is the possibility, for mutually untrusted parties, to interact with one another without relying on a third party trusted entity.
Di Pirro, Matteo
core  

IGR Token-Raw Material and Ingredient Certification of Recipe Based Foods Using Smart Contracts

Informatics, 2019
The use of smart contracts and blockchain tokens to implement a consumer trustworthy ingredient certification scheme for commingled foods, i.e., recipe based, food products is described.
Ricardo Borges dos Santos, Nunzio Marco Torrisi, Erick Reyann Kasai Yamada, Rodrigo Palucci Pantoni   +3 more
doaj   +1 more source

Influencia de la solidez y el número de álabes en una turbina de eje vertical tipo h-darrieus

Revista Politécnica, 2020
El siguiente estudio propone el análisis de una turbina hidrocinética de eje vertical tipo H-Darrieus que puede ser implementada en las regiones no interconectas al sistema eléctrico colombiano en especial las zonas costeras.
Nelson Eduardo Tobón Tobón, Kevin Alexander Henao González, Andrés Felipe Burbano Hernandez, Jorge Sierra Del Rio, Diego Andrés Hincapié Zuluaga   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research of electric power regeneration using automotive cooling fan (Enhancement of wind turbine power by installing high solidity rotor on vehicle)

Nihon Kikai Gakkai ronbunshu, 2015
This work aims at developing a new cooling fan for vehicle engine. This fan can operate as a cooling fan at low vehicle speed. At high vehicle speed, however, the fan is rarely used as a cooling fan. Therefore the fan can be used as a wind turbine, which
Shinichi ODA, Yutaka HASEGAWA, Hiroki SUZUKI, Tatsuo USHIJIMA, Hideki OOYA   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Towards Understanding the Bugs in Solidity Compiler

Solidity compiler plays a key role in enabling the development of smart contract applications on Ethereum by governing the syntax of a domain-specific language called Solidity and performing compilation and optimization of Solidity code.
Shen, Qingchao, Cheung, Shing-Chi, Tian, Yongqiang, Zhang, Wuqi, Chen, Junjie, Ma, Haoyang, Cheung, Shing Chi   +6 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Solidity ontology

, 2023
<p>Blockchain has become a pervasive technology in a wide number of sectors like industry, research, and academy. With the emergence of blockchain, new solutions with this technology to existing problems were devised, leading to the introduction of
Cano de Benito, Juan, Cimmino, Andrea, García Castro, Raúl   +2 more
core   +1 more source