Results 101 to 110 of about 12,187 (241)
The utilization of Solidity programming language in blockchain
Vojnotehnički GlasnikIntroduction/purpose: This work provides a comprehensive overview of blockchain technology, elucidating its foundational principles and how it ensures transparency, immutability, and decentralization.
Sava S. Stanišić +2 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Equilibrium conditions at a solid-solid interface [PDF]
AIP Conference Proceedings, 2011 We derive the thermodynamic conditions necessary for two elastoplastic solid phases to coexist in equilibrium. Beyond temperature, velocity, and traction continuity, these conditions require continuity of a generalization of the specific Gibbs free energy. We express this quantity in the Eulerian frame as well as the Lagrangian frame. We also show that
openaire +2 more sources
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Code differencing plays a crucial role in modern software engineering, helping developers quickly identify changes between versions. To enhance the accuracy and utility of these comparisons, Abstract Syntax Tree (AST) differencing provides a higher ...
Åryd, Viktor
core +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Integrating social media data into smart contracts
Електроніка та інформаційні технологіїThe rise of blockchain technology has set the stage for groundbreaking decentralized applications and smart contracts. Recently, there's been a surge in interest regarding the integration of social media data into blockchain-based smart contracts ...
Yurii Tsudzenko
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source