Results 111 to 120 of about 12,187 (241)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Defeasible logic reasoner to support legal reasoning in smart contracts on blockchain

Frontiers in Blockchain
The introduction of information and communication technologies in the legal domain has enabled the automation of some activities in the legal profession.
Marko Marković, Stevan Gostojić
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Independent Effects of Blade Number and Solidity on Cyclorotor Hover Performance: A Parametric CFD Study for Design Optimization

Aerospace
The influence of blade number and rotor solidity on cyclorotor hover performance remains insufficiently understood because previous studies have generally varied these parameters simultaneously or investigated them through separate one-factor analyses ...
Anwer Altahir Mohamed Alsabri, Ognjen Peković, Nikola Mirkov, Aleksandar Simonović, Aleksandar Grbović   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Assessing GitHub Copilot in Solidity Development: Capabilities, Testing, and Bug Fixing

IEEE Access
In the rapidly evolving landscape of blockchain technology, the development of reliable and secure smart contracts represents one of several crucial challenges.
Gavina Baralla, Giacomo Ibba, Roberto Tonelli   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Seed Morphometry Reveals Two Major Groups in Spanish Grapevine Cultivars

Plants
Seed morphological description requires quantitative methods for further comparison. Here, traditional measurements, curvature analysis, and the J-index (percentage of similarity to a geometric model) were applied to the average contours (Acs) of 271 ...
José Javier Martín-Gómez, José Luis Rodríguez-Lorenzo, Francisco Emanuel Espinosa-Roldán, Félix Cabello Sáenz de Santamaría, Gregorio Muñoz-Organero, Ángel Tocino, Emilio Cervantes   +6 more
doaj   +1 more source

Continuity vs Solidity

, 2020
Data from the experiments reported in "Core cognition in adult vision: A surprising discrepancy between the principles of object continuity and solidity", by Falck, Labouret, Izard, Wertz, Keil & Strickland (JEP:General, July 13, 2020)
Andreas Falck, Frank Keil, Véronique Izard, Annie Wertz, Ghislaine Labouret, Brent Strickland   +5 more
core