Results 131 to 140 of about 900,679 (330)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

FRAGILIDADE AMBIENTAL DA BACIA DO RIO PEQUENO EM SÃO JOSÉ DOS PINHAIS (PR)

Geografia (Londrina), 2013
O presente trabalho teve o objetivo de identificar e avaliar a fragilidade ambiental da bacia do rio Pequeno, situada no município de São José dos Pinhais (PR). A fragilidade ambiental foi determinada baseando-se em dados de solo e declividade.
Marcia Regina Gomes de Jesus Soares, Jorge Luiz Moretti de Souza, Daniela Jerszurki   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Discriminação entre solos formados em região transicional por meio de sua resposta espectral

Bioscience Journal, 2013
Os levantamentos pedológicos são amplamente utilizados nos mapeamentos de solo por serem métodos confiáveis, no entanto, apesar de tal vantagem são demorados e trabalhosos.
Everson Cezar, Marcos Rafael Nanni, Marcelo Luiz Chicati, Roney Berti de Oliveira, José Alexandre Melo Demattê   +4 more
doaj  

Produção de grãos de sete cultivares de milho em três latossolos da região de Sete Lagoas, MG. [PDF]

, 2018
Os resultados interativos entre cultivares de milho, algumas das quais materiais experimentais, e as condicoes edaficas e climaticas prevalentes durante o ciclo de desenvolvimento das plantas, constituiram a meta principal do ensaio realizado em ...
AVELAR, B. C., GAMA, E. E. G., VASCONCELLOS, C. A.   +2 more
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Sistema de Informação de solos brasileiros. [PDF]

, 2011
Com o objetivo de possibilitar o armazenamento e a disponibilização das informações sobre os solos brasileiros, a Embrapa Informática Agropecuária e a Embrapa Solos investem no desenvolvimento de um Sistema de Informações de Solos.
LIMA JÚNIOR, F. A. de, MEIRELLES, M. S. P., OLIVEIRA, S. R. de M., SANTOS, H. G. dos, ZURMELY, H. R.   +4 more
core  

Clustering of Musical Pieces through Complex Networks: an Assessment over Guitar Solos

, 2017
Musical pieces can be modeled as complex networks. This fosters innovative ways to categorize music, paving the way towards novel applications in multimedia domains, such as music didactics, multimedia entertainment and digital music generation ...
Ferretti, Stefano
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source