Results 1 to 10 of about 2,048,035 (343)
Protein Design: From the Aspect of Water Solubility and Stability
Chemical Reviews, 2022 Water solubility and structural stability are key merits for proteins defined by the primary sequence and 3D-conformation. Their manipulation represents important aspects of the protein design field that relies on the accurate placement of amino acids ...
Rui Qing, Shilei Hao, Arthur O Zalevsky
exaly +2 more sources
IUPAC Standards Online, 2019 Aqueous solubility is the concentration of the chemical in the aqueous phase, when the solution is in equilibrium with the pure compound in its usual phase (gas, liquid or solid) at a specified temperature and pressure (e.g., 25°C, 1 atm).
Maria F. Camões +2 more
openaire +2 more sources
Pharmaceutics, 2022 Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in double ...
Boris Peklar +6 more
doaj +1 more source
Image-based dissolution analysis for tracking the surface stability of amorphous powders
ADMET and DMPK, 2020 Poor solubility of crystalline drugs can be overcome by amorphization – the production of high-energy disordered solid with improved solubility.
Jernej Štukelj +4 more
doaj +1 more source
Solids, colloids, and the hydrolysis of tetravalent uranium in chloride media
Frontiers in Nuclear Engineering, 2023 Understanding of the properties of dissolution and precipitation of Uranium under reducing geochemical conditions is important in radioactive waste management and assessments of natural uranium deposits. The mechanism of forming UO2+y from U(VI) and U(IV)
B. Grambow +4 more
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2023 In this paper, it is proposed to consider a new method developed for studying the kinetics of release of substances that are poorly soluble in aqueous media on the example of quercetin. The study object was the drug containing plant bioactive components –
Nataliia V. Khanina +3 more
doaj +1 more source
On the Solubility and Stability of Polyvinylidene Fluoride
Polymers, 2021 This literature review covers the solubility and processability of fluoropolymer polyvinylidine fluoride (PVDF). Fluoropolymers consist of a carbon backbone chain with multiple connected C–F bonds; they are typically nonreactive and nontoxic and have ...
J. Marshall +8 more
semanticscholar +1 more source
Pharmaceutics, 2023 Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism.
Ayşe Kaya +6 more
doaj +1 more source
Pharmaceuticals, 2023 Bedaquiline has been approved as a combination therapy to treat multi-drug-resistant tuberculosis in adults ≥ 18 years old. The citrate, fumarate, phosphate, and tartrate salts have obtained patents, but the structures for these moieties have not been ...
Mercy A. Okezue, Stephen R. Byrn
doaj +1 more source
Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent
Proceedings, 2017 : Flurbiprofen (FB) is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) which has low water solubility (1). In recent studies it is shown that NSAIDs tend to demonstrate chemopreventive activity and chemoprotective agents frequently show low ...
Ayşe Nur Oktay +2 more
doaj +1 more source