Results 1 to 10 of about 1,117,205 (307)

Image-based dissolution analysis for tracking the surface stability of amorphous powders

ADMET and DMPK, 2020
Poor solubility of crystalline drugs can be overcome by amorphization – the production of high-energy disordered solid with improved solubility.
Jernej Štukelj, Mikael Agopov, Jouko Yliruusi, Clare J. Strachan, Sami Svanbäck   +4 more
doaj   +1 more source

Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]

, 2020
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham, Chen, Xing, Nikolakakis, Ioannis, Partheniadis, Ioannis   +3 more
core   +1 more source

Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment

Pharmaceutics, 2023
Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism.
Ayşe Kaya, Basel Arafat, Havovi Chichger, Ibrahim Tolaymat, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah   +6 more
doaj   +1 more source

Controlled Drug Release Asymptotics [PDF]

, 1998
The solution of Higushi's model for controlled release of drugs is examined when the solubility of the drug in the polymer matrix is a prescribed function of time. A time-dependent solubility results either from an external control or from a change in pH
Cohen, Donald S., Erneux, Thomas
core   +1 more source

Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent

Proceedings, 2017
: Flurbiprofen (FB) is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) which has low water solubility (1). In recent studies it is shown that NSAIDs tend to demonstrate chemopreventive activity and chemoprotective agents frequently show low ...
Ayşe Nur Oktay, Sibel İlbasmiş Tamer, Nevin Çelebi   +2 more
doaj   +1 more source

Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar [PDF]

, 1992
The compositional dependence of H2O solubility was investigated at 2 kbar and 800°C in haplogranite melts (system SiO2---1bNaAlSi3O8---1bKAlSi3O8 or Qz---1bAb---1bOr).
Blamart, Burnham, Burnham, Burnham, Day, Dingwell, Dingwell, Dingwell, Dingwell, Dingwell, Donald B. Dingwell, François Holtz, Friedman, Goranson, Hamilton, Harald Behrens, Holtz, Kennedy, Khitarov, Kohn, Lapham, Luth, Luth, McMillan, Mysen, Nabelek, Orlova, Oxtoby, Oxtoby, Pichavant, Pichavant, Pichavant, Richard P. Taylor, Silver, Silver, Stolper, Turek, Tuttle, Urbain, Voigt, Westrich, Zhang   +41 more
core   +1 more source

The Ethaline Effect on Feruloyl Esterase Activity

Proceedings, 2019
In recent years, extractions using natural deep eutectic. [...]
Ioana-Cristina Marinaș, Bogdan Trică, Carmen-Valentina Nicolae, Florin Oancea, Diana Constantinescu-Aruxandei   +4 more
doaj   +1 more source

Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]

, 2006
The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
A.A. Hernandez Santiago, Coffman, Coffman, D.B. Davies, Datta, Davies, Evstigneev, Evstigneev, Fawzi, Hussain, Jain, Khalil, Larsen, Lim, M.P. Evstigneev, Rasool, Redenti, Ribeiro, V.P. Evstigneev, Veselkov, Veselkov, Veselkov, Veselkov   +22 more
core   +1 more source

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

IUPAC-NIST solubility data series. 81. Hydrocarbons with water and seawater - Revised and updated. Part 8. C9 hydrocarbons with water [PDF]

, 2005
The mutual solubility and related liquid-liquid equilibria of C9 hydrocarbons with water are exhaustively and critically reviewed. Reports of the experimental determination of solubility in 18 chemically distinct binary systems that appeared in the ...
Blazej, K., Goral, M., Haulait-Pirson, M-C., Hefter, G.T., Kapuku, F., Maczynska, Z., Maczynski, A., Owczarek, I., Shaw, D.G., Skrzecz, A., Szafranski, A., Wisniewska-Goclowska, B.   +11 more
core   +2 more sources