Results 91 to 100 of about 527,537 (317)
Further considerations to improve the druggability of biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]
Exploration of Drug ScienceBuarque et al. (Explor Drug Sci. 2025;3:1008107. DOI: 10.37349/eds.2025.1008107) reported the synthesis of 13 biaryl hydroxy-1,2,3-triazoles and 11 fluorene-1,2,3-triazole hybrids via optimized Suzuki and telescopic one-pot reactions.
Zhiqi Liu, Meihong Zhang, Zhengwei Huang
doaj +1 more source
Computing the aqueous solubility of organic drug-like molecules and understanding hydrophobicity
, 2015 This thesis covers a range of methodologies to provide an account of the current (2010-2014) state of the art and to develop new methods for solubility prediction.
Mcdonagh, James, McDonagh, James L.
core
Preparation and solubility of hydroxyapatite
, 1968 Two portions of a synthetic hydroxyapatite (HA), Ca5OH(PO4)3, fully characterized by x-ray, infrared, petrographic, and chemical analyses, were heated at 1,000 C in air and steam atmospheres, respectively.
Moreno, E.C.; Gregory, T.M.; Brown, W.E.
core +1 more source
jeah-z/Aqueous-solubility-prediction-with-GCN 0.1
, 2020 This release is created with the paper "Accurate Predictions of Aqueous Solubility of Drug Molecules via Multilevel Graph Convolutional Network (MGCN) and SchNet Architectures"
Jie Zhang
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids
, 2001 Ethyne was probably first made in the laboratory by Edmund Davy in 1836. It was rediscovered nearly a quarter of a century later by Berthelot who gave it the name acetylene.
Derrick, M.E. +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
THE SOLUBILITY OF CERTAIN DIFFICULTLY SOLUBLE SILVER SALTS. [PDF]
Journal of the American Chemical Society, 1915 n ...
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source