Results 141 to 150 of about 527,537 (317)

Triboelectrification and dissolution property enhancements of solid dispersions

, 2015
The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles.
Conway, Barbara R, Hiba Al-Hamidi (16203491), Šupuk, Enes, Conway, Barbara R., Kofi Asare-Addo (4172488), Al-Hamidi, Hiba, Owusu-Ware, Samuel, Asare-Addo, Kofi, Samuel Owusu-Ware (16228529), Barbara R. Conway (4172491), Enes Šupuk (16228532), Nokhodchi, Ali, Ali Nokhodchi (4465915)   +12 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluating the Solubility of Endodontic Sealers in Response to Static and Dynamic Stress: An In Vitro Study

European Endodontic Journal
Objective: This study investigated the effect of static and dynamic conditions on the solubility of three en-dodontic sealers: AH Plus (an epoxy-resin-based sealer), Bio-C Sealer (a bioceramic sealer), and EndoSequence BC (a bioceramic sealer).
Mohammad Ali Saghiri, Mahsa Amanabi, Elham Samadi, Armen Asatourian, Fatereh Samadi, Steven M. Morgano   +5 more
doaj   +1 more source

The concentration of homocysteine-derived disulfides in human coronary artery

, 2007
*Background* Based on previous findings, we have estimated that, in injured coronary artery tissue, the low molecular weight disulfides homocystine and cysteine-homocysteine, otherwise identified as oxidized homocysteine equivalents (OHcyE ...
Liberato Ciavatta, Mauro Iuliano, Raffaele Ragone, Gaetano De Tommaso   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Polymorph-Specific Solubility Prediction using Constant Chemical Potential Molecular Dynamics

Molecular Dynamics (MD) simulations offer a robust approach to understanding material properties within a system. Solubility is defined as the analytical composition of a saturated solution expressed as a proportion of designated solute in a designated ...
Tarak, Karmakar, Aashutosh, Soni, , Neha, Manya, Aggarwal   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

An Approach to Enhance the Solubility of an Atypical Antipsychotic Drug, Aripiprazole: Design, Characterization, and Evaluation of Arabinoxylan-Based Nanoparticles

Nanotechnology, Science and Applications
Mehwish Sikander,1 Ume Ruqia Tulain,1 Nadia Shamshad Malik,2 Arshad Mahmood,3,4 Mohammed S Alqahtani,5 Alia Erum,1 Muhammad Tariq Khan2,6 1Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan; 2Faculty of Pharmacy, Capital University of ...
Sikander M, Tulain UR, Malik NS, Mahmood A, Alqahtani MS, Erum A, Khan MT   +6 more
doaj  

EFFECT OF SOLUBILITY ENHANCERS ON THE SOLUBILITY OF PARACETAMOL

, 2013
Solubility plays an important role in dissolution and absorption of drug. Paracetamol has less solubility in aqueous media and belongs to class IV drug according to biopharmaceutical classification system.The aim of present study was to study the effect of different solubility enhancing agents at room temperature on the solubility of paracetamol ...
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source