Results 11 to 20 of about 1,433,465 (359)

Synthesis, Characterization, and Stability Assessment for the Benzoate, Hydrochloride, Malonate, and Nicotinate Salts of Bedaquiline

open access: yesPharmaceuticals, 2023
Bedaquiline has been approved as a combination therapy to treat multi-drug-resistant tuberculosis in adults ≥ 18 years old. The citrate, fumarate, phosphate, and tartrate salts have obtained patents, but the structures for these moieties have not been ...
Mercy A. Okezue, Stephen R. Byrn
doaj   +1 more source

Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent

open access: yesProceedings, 2017
: Flurbiprofen (FB) is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) which has low water solubility (1). In recent studies it is shown that NSAIDs tend to demonstrate chemopreventive activity and chemoprotective agents frequently show low ...
Ayşe Nur Oktay   +2 more
doaj   +1 more source

Solubility of baclofen in 1-hexyl-4-methylpyridinium bromide + water binary mixtures [PDF]

open access: yesشیمی کاربردی روز, 2017
In this paper, solubility of baclofen was studied by gravimetric method. The solubility of baclofen was measured in (water + 1-hexyl-4-methylpyridinium bromide) binary mixtures from 293.1 K to 313.1 K under atmosphere pressure.
Abbas Mehrdad   +2 more
doaj   +1 more source

The Ethaline Effect on Feruloyl Esterase Activity

open access: yesProceedings, 2019
In recent years, extractions using natural deep eutectic. [...]
Ioana-Cristina Marinaș   +4 more
doaj   +1 more source

Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles [PDF]

open access: yesPharmaceutical Sciences
Background: Administering Cinacalcet HCl (CINA) can be challenging because of its low oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor aqueous solubility.
Katayoon Mireskandari   +4 more
doaj   +1 more source

EFFECT OF SOLUBILITY ENHANCERS ON THE SOLUBILITY OF PARACETAMOL [PDF]

open access: yesIndo American Journal of Pharmaceutical Research, 2013
Solubility plays an important role in dissolution and absorption of drug. Paracetamol has less solubility in aqueous media and belongs to class IV drug according to biopharmaceutical classification system.The aim of present study was to study the effect of different solubility enhancing agents at room temperature on the solubility of paracetamol ...
Joshi Ha, Patil Rn, Dyade Gk
openaire   +2 more sources

Theoretically Guided Analytical Method Development and Validation for the Estimation of Rifampicin in a Mixture of Isoniazid and Pyrazinamide by UV Spectrophotometer

open access: yesFrontiers in Chemistry, 2017
A simple, rapid, economic, accurate, and precise method for the estimation of rifampicin in a mixture of isoniazid and pyrazinamide by UV spectrophotometeric technique (guided by the theoretical investigation of physicochemical properties) was developed ...
Mohammad F. Khan   +11 more
doaj   +1 more source

Thymoquinone-Loaded Soluplus®-Solutol® HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration

open access: yesMolecules, 2020
Thymoquinone (TQ) is the main active ingredient of Nigella sativa essential oil, with remarkable anti-neoplastic activities with anti-invasive and anti-migratory abilities on a variety of cancer cell lines.
Maria Camilla Bergonzi   +4 more
doaj   +1 more source

Protein–Sol: a web tool for predicting protein solubility from sequence

open access: yesBioinform., 2017
Motivation: Protein solubility is an important property in industrial and therapeutic applications. Prediction is a challenge, despite a growing understanding of the relevant physicochemical properties. Results: Protein‐Sol is a web server for predicting
M. Hebditch   +4 more
semanticscholar   +1 more source

Solubility and phase equilibria in the Na, Са || СО3, НСО3–H2O system at 0 °С

open access: yesChimica Techno Acta, 2017
The information on phase equilibria in the Na, Ca || CO3, HCO3-H2O system at 0 °С, predicted earlier by the translation method, has been obtained experimentally. Dependences of the concentration parameters reflecting phase equilibria are presented in the
L. Soliev   +2 more
doaj   +1 more source

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