Results 171 to 180 of about 1,040,538 (251)

Formulation and Evaluation of Indomethacin Nanosuspensions Stabilized by Poly(2-oxazine) and Poly(2-oxazoline)-Based Polymers for Solubility Enhancement. [PDF]

Pharm Res
Espo E, Potdar D, Baas K, Keßler L, Yang M, Bērziņš K, Kemell M, Kiiskinen T, Heinonen A, Kehrein J, Boyd BJ, Karttunen AP, Peltonen L, Luxenhofer R, Bunker A, Viitala T.   +15 more
europepmc   +1 more source

Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies. [PDF]

J Enzyme Inhib Med Chem, 2021
Sid D, Baitiche M, Elbahri Z, Djerboua F, Boutahala M, Bouaziz Z, Le Borgne M.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Selection of Solubility Enhancement Technologies for S-892216, a Novel COVID-19 Drug Candidate. [PDF]

Pharmaceutics
Ohashi R, Otake S, Murata T, Watari R, Yoshida S, Kitade M, Kondo D, Kimura G.   +7 more
europepmc   +1 more source

Experimental and Theoretical Study on Theobromine Solubility Enhancement in Binary Aqueous Solutions and Ternary Designed Solvents. [PDF]

Pharmaceutics, 2021
Jeliński T, Stasiak D, Kosmalski T, Cysewski P.   +3 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

MEDICAL ENHANCEMENT AND POSTHUMANITY

, 2009
Introduction / Bert Gordijn and Ruth Chadwick -- Pt. I. Medical enhancement -- 1. The history of medical enhancement: from Restitutio ad Integrum to Transformatio ad Optimum? / Urban Wiesing -- 2. Therapy, enhancement and improvement / Ruth Chadwick --

core  

Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition. [PDF]

Pharmaceuticals (Basel), 2021
Lee JH, Park C, Weon KY, Kang CY, Lee BJ, Park JB.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

In Silico Preformulation Modeling, Solubility Enhancement, and Sustainable Release of Rebamipide Utilizing Deep Eutectic Mixture Loaded Bioadhesive Controlled Release Granules for Gastritis Treatment. [PDF]

Pharmaceutics
Almajidi YQ, Al-Hakeem MA, Yaseen A.
europepmc   +1 more source