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Expression, Solubilization, and Refolding Recovery of a Novel l‑Asparaginase-Arginase 1 Chimera from <i>E. coli</i> Inclusion Bodies. [PDF]
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Journal of Pharmaceutical Sciences, 1999
Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation.
L, Zhao, P, Li, S H, Yalkowsky
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Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation.
L, Zhao, P, Li, S H, Yalkowsky
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International Journal of Pharmaceutics, 2001
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol.
P, Simamora +2 more
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The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol.
P, Simamora +2 more
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Current Protocols in Immunology, 2003
AbstractPurification and study of transmembrane proteins require isolation of these structures from their lipid environment. This isolation is carried out through the use of detergents. In this unit, several approaches to solubilization of membrane proteins are presented.
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AbstractPurification and study of transmembrane proteins require isolation of these structures from their lipid environment. This isolation is carried out through the use of detergents. In this unit, several approaches to solubilization of membrane proteins are presented.
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Solubilization of Aminopteridines
Journal of Pharmaceutical Sciences, 1968Aqueous solutions of a series of aminopteridines (5—10 mg./ml.) stable at physiologic pH's were prepared either by salt formation with hydrochloric acid or by complex formation with 10 percent deoxyribonucleic acid. Deoxyribonucleic acid was superior to ribonucleic acid, crystalline bovine serum albumin, human serum albumin fraction V, or gum acacia in
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Solubilization of membranes by detergents
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1975This review focuses on work that deals with the mechanisms of detergent action in membrane solubilization including properties of detergents model lipid systems and detergent-protein interactions; in addition a possible sequence of events when detergents interact with biological membranes receives attention. More specific topics include: 1) properties
A, Helenius, K, Simons
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Solubilization in nonionic microemulsions
Colloids and Surfaces, 1989Solubilization of aqueous solutions in microemulsions containing nonionic surfactants has been investigated. The microemulsions are oil-continuous and free of any cosolvent or cosurfactant. The effects of electrolyte type and concentration, hydrocarbon chain length, and temperature on solubilization have been determined experimentally. Depending on the
S. Qutubuddin, J. M. Wiencek
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Hydrolysis of solubilized esters
Journal of Pharmaceutical Sciences, 1967The solubilizing ability of four nonionic surface-active agents is quantitatively compared. The critical micelle concentration (CMC) of the surface-active agents was evaluated from the solubility curves. The effect of the surface-active agents on the rate of hydrolysis of benzocaine and homatropine was investigated. At a concentration of surface-active
P B, Sheth, E L, Parrott
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Solubilization in monodisperse emulsions
Journal of Colloid and Interface Science, 2007The kinetics of oil solubilization into micelles from nearly monodisperse alkane-in-water emulsion droplets was investigated. Emulsions containing either hexadecane or tetradecane oils were fractionated to be narrowly distributed, using a method developed by Bibette [J. Bibette, J. Colloid Interface Sci. 147 (1991) 474].
Suwimon, Ariyaprakai +1 more
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Cyclodextrins as pharmaceutical solubilizers
Advanced Drug Delivery Reviews, 2007Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility.
Marcus E, Brewster, Thorsteinn, Loftsson
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