Results 241 to 250 of about 176,621 (285)
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Journal of Pharmaceutical Sciences, 1999
Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation.
L, Zhao, P, Li, S H, Yalkowsky
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Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation.
L, Zhao, P, Li, S H, Yalkowsky
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International Journal of Pharmaceutics, 2001
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol.
P, Simamora +2 more
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The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol.
P, Simamora +2 more
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Solubilization of inorganic calcium phosphates—Solubilization mechanisms
Soil Biology and Biochemistry, 1995Abstract Two species [Penicillium aurantiogriseum and Pseudomonas sp. ( PI18 89 )] having high abilities in solubilizing inorganic phosphates (hydroxylapatite and brushite) were used to examine solubilization mechanisms. No direct contact between microorganisms and calcium phosphates (Ca-Ps) were necessary for effective solubilization.
P. Illmer, F. Schinner
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Membrane Protein Solubilization
2009A critical step in any in vitro analysis of membrane proteins is the solubilization of the membrane to extract the protein of interest in an active form to obtain an aqueous solution containing the membrane protein complexed with detergents and lipids in a form suitable for purification and further analysis. This process is particularly delicate as the
Katia, Duquesne, James N, Sturgis
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Journal of the American Oil Chemists' Society, 2018
AbstractTo address the anticipated global need for increased protein supply for human nutrition, particularly for developing and underdeveloped regions, concerted efforts are required. Although animal proteins satisfy nutrition needs, they may not be acceptable to all consumers either due to their cost or dietary restrictions followed by the consumer ...
Shridhar K. Sathe +3 more
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AbstractTo address the anticipated global need for increased protein supply for human nutrition, particularly for developing and underdeveloped regions, concerted efforts are required. Although animal proteins satisfy nutrition needs, they may not be acceptable to all consumers either due to their cost or dietary restrictions followed by the consumer ...
Shridhar K. Sathe +3 more
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Current Protocols in Immunology, 2003
AbstractPurification and study of transmembrane proteins require isolation of these structures from their lipid environment. This isolation is carried out through the use of detergents. In this unit, several approaches to solubilization of membrane proteins are presented.
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AbstractPurification and study of transmembrane proteins require isolation of these structures from their lipid environment. This isolation is carried out through the use of detergents. In this unit, several approaches to solubilization of membrane proteins are presented.
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Solubilization of Aminopteridines
Journal of Pharmaceutical Sciences, 1968Aqueous solutions of a series of aminopteridines (5—10 mg./ml.) stable at physiologic pH's were prepared either by salt formation with hydrochloric acid or by complex formation with 10 percent deoxyribonucleic acid. Deoxyribonucleic acid was superior to ribonucleic acid, crystalline bovine serum albumin, human serum albumin fraction V, or gum acacia in
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Solubilization in nonionic microemulsions
Colloids and Surfaces, 1989Solubilization of aqueous solutions in microemulsions containing nonionic surfactants has been investigated. The microemulsions are oil-continuous and free of any cosolvent or cosurfactant. The effects of electrolyte type and concentration, hydrocarbon chain length, and temperature on solubilization have been determined experimentally. Depending on the
S. Qutubuddin, J. M. Wiencek
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