Results 251 to 260 of about 176,621 (285)

Hydrotropic Solubilization— Mechanistic Studies

Pharmaceutical Research, 1996
This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism for hydrotropic solubilization is complexation, and therefore, is investigated. Additionally, since nicotinamide and several other hydrotropic agents self-associate in aqueous solution, the possibility that self-
R E, Coffman, D O, Kildsig
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Cyclodextrins as pharmaceutical solubilizers

Advanced Drug Delivery Reviews, 2007
Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility.
Marcus E, Brewster, Thorsteinn, Loftsson
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Hydrolysis of solubilized aspirin

Journal of Pharmaceutical Sciences, 1967
The hydrolysis of aspirin in buffered solutions of the nonionic surfactant, cetomacrogol, has been studied at 37° over the pH range 1 through 7. Cetomacrogol reduces the hydrolysis rate of unionized aspirin but not that of ionized aspirin. The reaction occurs mainly in the aqueous phase but at low pH the contribution of a hydrogen ion catalyzed ...
A G, Mitchell, J F, Broadhead
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Solubilization of NSC-639829

International Journal of Pharmaceutics, 2001
Solubilization using pH combined with cosolvents, surfactants, and complexants are investigated for NSC-639829, an investigational anti-tumor agent. The intrinsic solubility of the drug is approximately 30 ng/ml and it has an ionizable dimethyl aniline group with an approximate base pK(a) of 5.
N, Jain, G, Yang, S E, Tabibi, S H, Yalkowsky   +3 more
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Solubilization in monodisperse emulsions

Journal of Colloid and Interface Science, 2007
The kinetics of oil solubilization into micelles from nearly monodisperse alkane-in-water emulsion droplets was investigated. Emulsions containing either hexadecane or tetradecane oils were fractionated to be narrowly distributed, using a method developed by Bibette [J. Bibette, J. Colloid Interface Sci. 147 (1991) 474].
Suwimon, Ariyaprakai, Stephanie R, Dungan   +1 more
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Elastin purification and solubilization

2018
The functional form of elastin is a highly cross-linked polymer that organizes as sheets or fibers in the extracellular matrix. Purification of the mature protein is problematic because its insolubility precludes its isolation using standard wet-chemistry techniques.
Carmen M, Halabi, Robert P, Mecham
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[Gallstone solubilizers].

Nihon Geka Gakkai zasshi, 1984
In spite of the great progress seen in the diagnostic and treating method for gallstone patients in this 10 years, the criteria of the operative indication for these patients have not been discussed for a long time. I wish to emphasize it is high time for us to examine a matter, since chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) have ...
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Membrane Preparation and Solubilization

2015
Membrane proteins play an essential role in several biological processes like ion transport, signal transduction, and electron transfer to name a few. For structural and functional studies of integral membrane proteins, it is critically important to isolate proteins from the membrane using biological detergents.
openaire   +2 more sources

Solubilizations-isothermen/ Solubilization Isotherms

Tenside Surfactants Detergents, 1988
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SOLUBILIZATION

2017
Raghavendra Kumar Gunda, J.N.SURESH KUMAR, A.M.SUDHAKAR BABU   +2 more
openaire   +1 more source