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Enzymatic Characterization of Human Soluble Epoxide Hydrolase
Enzymatic Characterization of Human Soluble Epoxide Hydrolaseopenaire
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International Journal of Biological Macromolecules, 2020
The inhibition of soluble epoxide hydrolase (sEH) is regarded as a promising therapeutic approach to treat inflammation and its related disorders. In present work, we investigated inhibitory effects of forty-nine kinds of traditional Chinese medicines against sEH.
Xin, He +9 more
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The inhibition of soluble epoxide hydrolase (sEH) is regarded as a promising therapeutic approach to treat inflammation and its related disorders. In present work, we investigated inhibitory effects of forty-nine kinds of traditional Chinese medicines against sEH.
Xin, He +9 more
openaire +2 more sources
International Journal of Biological Macromolecules, 2021
Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and 3β-hydroxy-alisol G (2) were isolated from Alisma orientale and identified ...
Wen-Yu, Zhao +9 more
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Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and 3β-hydroxy-alisol G (2) were isolated from Alisma orientale and identified ...
Wen-Yu, Zhao +9 more
openaire +2 more sources
Polymorphisms in Human Soluble Epoxide Hydrolase
Molecular Pharmacology, 2003Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous substrates for hsEH. Enzyme activity in humans shows high interindividual variation (e.g., 500-fold in liver) suggesting the existence of regulatory and/or structural gene ...
Beata D, Przybyla-Zawislak +9 more
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Soluble epoxide hydrolase and ischemic cardiomyopathy
International Journal of Cardiology, 2012The development of cardiovascular disease has been linked to lowered levels of epoxyeicosatrienoic acids (EETs) in the cardiovascular system. Ischemic cardiomyopathy is caused by atherosclerotic lesions in multi-coronary arteries especially diffusive lesions, which can lead to severe myocardial dysfunction, heart enlargement, heart failure, or ...
Ting-Ting, Zhao +5 more
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Phosphatase activity of soluble epoxide hydrolase
Prostaglandins & Other Lipid Mediators, 2017Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that exhibits lipid epoxide hydrolase (sEH-H) and lipid phosphatase activity (sEH-P), with each being located in its own distinct domain. While the epoxide hydrolase activity is well-investigated, the role of the phosphatase domain remains unclear.
Jan, Kramer, Ewgenij, Proschak
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Epoxylipids and soluble epoxide hydrolase in heart diseases
Biochemical Pharmacology, 2022Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks.
John D, Imig +2 more
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Measurement of Soluble Epoxide Hydrolase (sEH) Activity
Current Protocols in Toxicology, 2007AbstractThe human soluble epoxide hydrolase (sEH; EC 3.3.3.2) is the product of the EXPH2 gene. The sEH catalyzes the addition of a water molecule to an epoxide, resulting in the corresponding diol. Early work suggested a role of sEH in detoxifying a wide array of xenobiotic epoxides; however, recent findings clearly implicate the sEH in the regulation
Christophe, Morisseau, Bruce D, Hammock
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Soluble Epoxide Hydrolase Inhibitors and Cardiovascular Diseases
Current Vascular Pharmacology, 2012Epoxyeicosatrienoic acids (EETs) have been shown to play a role in cardiovascular protection by reducing ischemia reperfusion injury, producing anti-inflammatory effects, and promoting angiogenesis. EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH).
Zhen-He, Wang +4 more
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Brassica napus soluble epoxide hydrolase (BNSEH1).
European journal of biochemistry, 2002Epoxide hydrolase (EC 3.3.2.3) in plants is involved in the metabolism of epoxy fatty acids and in mediating defence responses. We report the cloning of a full-length epoxide hydrolase cDNA (BNSEH1) from oilseed rape (Brassica napus) obtained by screening of a cDNA library prepared from methyl jasmonate induced leaf tissue, and the 5'-RACE technique ...
Stefan, Bellevik +2 more
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