Results 231 to 240 of about 15,414 (258)
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The role of soluble epoxide hydrolase in preeclampsia
Medical Hypotheses, 2017Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation. Because termination of pregnancy results in the most efficacious resolution of preeclampsia, it is a leading cause of premature delivery worldwide.
Julia M. Santos +5 more
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Soluble epoxide hydrolase inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 2010Soluble epoxide hydrolase (sEH) inhibitors have been shown to effectively increase the levels of epoxyeicosatrienoic acids and reduce the levels of dihydroxyeicosatrienoic acids, which may be translated to therapeutic potentials for multiple disease indications. It has been claimed that sEH inhibitors can be used to treat hypertension, diabetes, stroke,
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Isolation and characterization of Xenopus soluble epoxide hydrolase
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014Soluble epoxide hydrolase (sEH) contributes to cell growth, but the contribution of sEH to embryonic development is not well understood. In this study, Xenopus sEH cDNA was isolated from embryos of Xenopus laevis. The Xenopus sEH was expressed in Escherichia coli and was purified.
Endang R, Purba +2 more
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Diabetic CVD – Soluble Epoxide Hydrolase as A Target
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2012The incidence of cardiovascular diseases remains high in diabetic patients despite the optimization of blood glucose control and the therapeutic management of risk factors. One emerging promising pharmacological approach that may help to prevent the development of diabetic cardiovascular complications is to improve endothelial function through the ...
Aurelien, Lorthioir +3 more
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Cardiovascular Therapeutic Aspects of Soluble Epoxide Hydrolase Inhibitors
Cardiovascular Drug Reviews, 2006ABSTRACTSoluble epoxide hydrolase (sEH) is an enzyme responsible for the conversion of lipid epoxides to diols by the addition of water. Biological actions on the cardiovascular system that are attributed to epoxides include vasodilation, antiinflammatory actions and vascular smooth muscle cell antimigratory actions.
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[Soluble epoxide hydrolase and lipid metabolism].
Sheng li ke xue jin zhan [Progress in physiology], 2012Soluble epoxide hydrolase (sEH) is widely distributed in mammalian tissues. Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, are degraded by sEH. EETs may function as antihypertensive and antiarthrosclerotic mediators for vasculature. Therefore, sEH is closely related with cardiovascular diseases and inflammation.
Xin-Xin, Ma, Yan, Liu, Yi, Zhu
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Soluble Epoxide Hydrolase as a Stroke Target
2012Soluble epoxide hydrolase (sEH) is a promising therapeutic target for stroke. Both pharmacological inhibition and genetic knockout of sEH have shown protection in experimental models of cerebral ischemia. Additionally, human single-nucleotide polymorphisms in the gene that encodes for sEH, designated ephx2, have been correlated with stroke incidence ...
Jonathan W. Nelson, Nabil J. Alkayed
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Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
Nature, 2022Dietmar Funck +2 more
exaly
Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity
Nature Communications, 2022Erika Erickson, , Gerhard König
exaly