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Renal effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence [PDF]
Current Opinion in Pharmacology, 2015 Direct stimulation of soluble guanylate cyclase (sGC) is emerging as a potential new approach for the treatment of renal disorders. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), deficiency of which is implicated in the ...
Berthold Hocher +2 more
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Revisiting soluble guanylate cyclase pharmacology: Additive potential of stimulators and activators
Biomedicine and PharmacotherapyNitric oxide (NO) is a key gasotransmitter that binds to soluble guanylate cyclase (sGC), thereby stimulating cGMP production. Under disease conditions, reactive oxygen species disrupt this signaling by either: (1) scavenging NO, or (2) promoting heme ...
Ana Isabel Casas Guijarro +2 more
exaly +2 more sources
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Soluble Guanylate Cyclase Activators and Stimulators in Patients with Heart Failure
Current Cardiology Reports, 2023Bo Liang
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Soluble guanylate cyclase stimulators and their potential use: a patent review
Expert Opinion on Therapeutic Patents, 2021Markus Follmann +2 more
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Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947
Bioorganic and Medicinal Chemistry Letters, 2020Jisong Cui, Gino Salituro
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The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators
Angewandte Chemie - International Edition, 2013Markus Follmann +2 more
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Acidic triazoles as soluble guanylate cyclase stimulators
Bioorganic and Medicinal Chemistry Letters, 2011Katherine England +2 more
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Soluble Guanylate Cyclase Stimulators and Activators: Where are We and Where to Go?
Mini-Reviews in Medicinal Chemistry, 2019Chen Zhuo, Qi Chang, Zutao Yu
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