Results 31 to 40 of about 463,492 (156)

Heterogeneity in human soluble guanylate cyclase due to alternative splicing [PDF]

, 1991
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase.
Frändberg, Per-Anders, Johan Ahlner, Per-Anders Frändberg, Chhajlani, Vijay, Ahlner, Johan, Vijay Chhajlani, Axelsson, Krister L., Krister L. Axelsson, Jarl E.S. Wikberg, Wikberg, Jarl E.S.   +9 more
core   +1 more source

Exploring molecular targets in diabetic kidney disease [PDF]

Kidney Research and Clinical Practice, 2022
Diabetic kidney disease is the leading cause of end-stage kidney disease, and it remains a major challenge. Many factors, such as glomerular hyperfiltration, oxidative stress, inflammation, hypoxia, and epigenetics, are associated with the progression of
Sayako Maruno, Tetsuhiro Tanaka, Masaomi Nangaku   +2 more
doaj   +1 more source

Correction to: Soluble Guanylate Cyclase Stimulators and Activators.

, 2019
The chapter 'Soluble Guanylate Cyclase Stimulators and Activators' has now been made available open access under a CC BY 4.0 ...
Follmann, M, Johannes-Peter Stasch, Milne, GT, Sandner, P, Zimmer, DP, Daniel P. Zimmer, G. Todd Milne, Adrian Hobbs, Peter Sandner, Markus Follmann, Hobbs, A, Stasch, J-P   +11 more
core   +1 more source

cGMP becomes a drug target [PDF]

, 2012
Cyclic guanosine 3',5'-monophosphate (cGMP) serves as a second messenger molecule, which regulates pleiotropic cellular functions in health and disease.
Schlossmann, Jens, Jens Schlossmann, Elisabeth Schinner, Schinner, E.   +3 more
core   +2 more sources

Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications

Critical Care Research and Practice, 2012
The heme-protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide (NO). sGC is a heterodimeric enzyme with α and β subunits and contains a heme moiety essential for binding of NO and activation of the enzyme.
Bobby Nossaman, Edward Pankey, Philip Kadowitz   +2 more
doaj   +1 more source

The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

Scientific Reports, 2022
Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive.
Ellis Nelissen, Nina Possemis, Nick P. Van Goethem, Melissa Schepers, Danielle A. J. Mulder-Jongen, Lisa Dietz, Wiebke Janssen, Michael Gerisch, Jörg Hüser, Peter Sandner, Tim Vanmierlo, Jos Prickaerts   +11 more
doaj   +1 more source

Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches

Cells, 2022
The maturation of hemeprotein dictates that they incorporate heme and become active, but knowledge of this essential cellular process remains incomplete. Studies on chaperon Hsp90 has revealed that it drives functional heme maturation of inducible nitric
Mamta P. Sumi, Arnab Ghosh
doaj   +1 more source

Soluble Guanylate Cyclase Stimulators and Activators.

, 2019
When Furchgott, Murad, and Ignarro were honored with the Nobel prize for the identification of nitric oxide (NO) in 1998, the therapeutic implications of this discovery could not be fully anticipated.
Follmann, M, Johannes-Peter Stasch, Milne, GT, Sandner, P, Zimmer, DP, Daniel P. Zimmer, G. Todd Milne, Adrian Hobbs, Peter Sandner, Markus Follmann, Hobbs, A, Stasch, J-P   +11 more
core   +1 more source

Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritis [PDF]

, 2004
Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritis.BackgroundActivation of soluble guanylate cyclase and generation of cyclic 3′,5′-guanosine monophosphate (cGMP) is the main signal transducing event
Wang, Yingrui, Loof, Tanja, Krämer, Stephanie, Martini, Sebastian, Kron, Susanne, Neumayer, Hans-H, Peters, Harm   +6 more
core   +1 more source

Emerging Treatment Approaches to Improve Outcomes in Patients with Heart Failure

Cardiology Discovery, 2022
Heart failure (HF) is a major public health problem around the world. Although currently available therapies have improved outcomes, morbidity and mortality in patients with HF remain unacceptably high.
Barry H. Greenberg
doaj   +1 more source