Results 91 to 100 of about 30,038 (314)

The Cells of the Vasculature: Advances in the Regulation of Vascular Tone in the Brain and Periphery

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT The vasculature is a complex tissue in which multiple cell types coordinate the regulation of tissue perfusion in response to hemodynamic and biochemical signals. Advances in this field are continuing to deepen our understanding of the relative importance of these cell types through the body.
Luke S. Dunaway, William A. Mills III, Ukpong B. Eyo, Brant E. Isakson   +3 more
wiley   +1 more source

Soluble skew left braces and soluble solutions of the Yang-Baxter equation [PDF]

arXiv, 2023
The study of non-degenerate set-theoretic solutions of the Yang-Baxter equation calls for a deep understanding of the algebraic structure of a skew left brace. In this paper, the skew brace theoretical property of solubility is introduced and studied. It leads naturally to the notion of solubility of solutions of the Yang-Baxter equation.
arxiv  

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source

Natriuretic Peptides and Nitric Oxide Stimulate cGMP Synthesis in Different Cellular Compartments [PDF]

, 2006
Cyclic nucleotide-gated (CNG) channels are a family of ion channels activated by the binding of cyclic nucleotides. Endogenous channels have been used to measure cyclic nucleotide signals in photoreceptor outer segments and olfactory cilia for decades ...
Berkova, Zuzana, Hassell, Kathryn A., Morris, Andrew P., Piggott, Leslie A., Rich, Thomas C., Silberbach, Michael   +5 more
core   +2 more sources

Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase

Journal of Biological Chemistry, 2017
Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases.
Jessica A. Wales, Cheng-Yu Chen, Linda A. Breci, A. Weichsel, S. Bernier, J. Sheppeck, Robert M. Solinga, T. Nakai, P. Renhowe, Joon Jung, W. Montfort   +10 more
semanticscholar   +1 more source

Identification of new inhibitors of soluble guanylyl cyclase activity [PDF]

BMC Pharmacology and Toxicology, 2014
Objective Soluble guanylyl cyclase, (sGC) is an enzyme that can be activated endogenously by nitric oxide (NO). As its particulate counterparts, the role of the cytoplasmic sGC inside the cell is to convert GTP to the second messenger, cGMP. NO is produced by nitric oxide synthase during the conversion of l-arginine to l-citrulline.
Jagamya Vijayraghavan, Focco van den Akker   +1 more
openaire   +3 more sources

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease

BJU International, Volume 135, Issue 5, Page 810-817, May 2025.
Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Sophie L. Harding, Marcus M. Ilg, Stephen A. Bustin, David J. Ralph, Selim Cellek   +4 more
wiley   +1 more source

Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro

OncoTarget, 2016
Strategies for driving white adipose tissue (WAT) to acquire brown-like characteristics are a promising approach to reduce obesity. Liraglutide has been reported to active brown adipose tissue (BAT) thermogenesis and WAT browning by rapid ...
Endong Zhu, Yang Yang, Juanjuan Zhang, Yongmei Li, Chun-jun Li, Liming Chen, Bei Sun   +6 more
semanticscholar   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

BMC Pharmacology and Toxicology, 2015
Clinical background Obesity has reached pandemic dimensions and novel pharmacological therapies are urgently needed. Obesity is characterized by excessive fat storage in white adipose tissue (WAT), because of a positive energy balance. In contrast to WAT,
A. Pfeifer, Jennifer Etzrodt, L. Hoffmann   +2 more
semanticscholar   +2 more sources