Results 131 to 140 of about 30,038 (314)
Prophylactic vs. Therapeutic: DNA vaccine to metastatic colorectal cancer using molecular marker guanylyl cyclase-C [PDF]
, 2013 The role of heat-stable enterotoxin receptor guanylyl cyclase C (GCC) is well known for its aberrant chloride conductance in the intestinal epithelium in response to bacterial infection.
Khurana, MSII, Anmol
core +1 more source
Infinite Approximate Subgroups of Soluble Lie Groups [PDF]
arXiv, 2019 We study infinite approximate subgroups of soluble Lie groups. Generalising a theorem of Fried and Goldman we show that approximate subgroups are close, in a sense to be defined, to genuine connected subgroups. Building up on this result we prove a structure theorem for approximate lattices in soluble Lie groups.
arxiv
Journal of Neuroscience, 2015 The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling. The dual-substrate enzyme PDE10A is the most highly expressed PDE in striatal medium-sized spiny
F. Padovan-Neto +9 more
semanticscholar +1 more source
Solvability in groups with a chain condition on uniformly definable subgroups [PDF]
arXiv, 2019 We prove a structure theorem for periodic locally soluble groups satisfying a chain condition on intersections of relatively uniformly definable subgroups using results from the theory of stable groups. The result in particular shows that these groups are soluble, thus giving a model-theoretic and much simpler proof of a special case of a theorem of ...
arxiv
Molecules, 2019 Alkaloids derived from plants have shown great medicinal benefits, and are often reported for their use in cardiovascular disease management. Aristotelia chilensis (Molina) Stuntz (Maqui) has shown important medicinal properties in traditional useage. In
Fernando Romero +6 more
doaj +1 more source
Global Sensitivity Analysis of a Novel Signaling Network for Heart Growth With Local IGF1 Production
International Journal for Numerical Methods in Biomedical Engineering, Volume 41, Issue 2, February 2025.Signaling networks regulate heart growth through hormonal and mechanical factors, but their complexity makes qualitative analysis challenging. This study's global sensitivity analysis highlights key factors, including the significant impact of local insulin‐like growth factor 1 (IGF1) production in response to mechanical stretches, norepinephrine (NE),
Christian Bilas +6 more
wiley +1 more source
Interaction of NO-sensitive guanylyl cyclase with Src-like kinases [PDF]
, 2009 Poster presentation NO-sensitive guanylyl cyclases (soluble guanylyl cyclase, sGC) are among the key regulators of intracellular cGMP concentration. The mechanisms underlying NO-mediated activation of sGC are quite well understood, however, little is ...
Gross, Steffen +3 more
core
Four-Dimensional Neuronal Signaling by Nitric Oxide: A Computational Analysis [PDF]
, 2000 Nitric oxide (NO) is now recognized as a transmitter of neurons that express the neuronal isoform of the enzyme nitric oxide synthase. NO, however, violates some of the key tenets of chemical transmission, which is classically regarded as occurring at ...
Husbands, Phil +2 more
core +3 more sources
Heliyon, 2022 Herein, we present the structure-based design, synthesis and biological evaluation of novel mono- and di-carboxylic 3,4-dihydroquinoxalin-2(1H)-one derivatives as potential heme-independent activators of soluble guanylate cyclase (sGC).
Dionysios-Panagiotis Kintos +8 more
doaj
BMC Pharmacology and Toxicology, 2015 Chronic nitroglycerin (GTN) anti-ischemic therapy induces side effects such as nitrate tolerance and endothelial dysfunction. Both phenomena could be based on a desensitization/oxidation of the soluble guanylyl cyclase (sGC). Therefore, the present study
Paul Stamm +13 more
semanticscholar +1 more source