Transcriptional Regulation of Soluble Guanylyl Cyclase
, 2009 Each year cardiovascular disease causes over 4.3 million deaths in Europe and is the cause of nearly one in three deaths in the US. Nitric oxide (NO) is a toxic atmospheric gas which exists in tissues as a biological product of mammalian cells. It has been used to manage cardiovascular disease for over a century and to this day remains an important ...
openaire +3 more sources
The dynamics of H-bonds of the hydration shells of ions, ATPase and NE-activated adenylyl cyclase on the coupling of energy and signal transduction [PDF]
arXiv, 2012 Glycerol titration distinguished from free water the local hydration shell involved in ATPase transition from active to inactive, with cooperativity for water n=16. Rat brain cortex: NE-stimulated and its basal AC in the absence of free Mg2+, allows a refractive state of AC with negative cooperativity for MgATP and ATP4-.
arxiv
Acrylamide Analog as a Novel Nitric Oxide-Independent Soluble Guanylyl Cyclase Activator
Journal of Pharmacological Sciences, 2006 Soluble guanylyl cyclase (sGC) is a target enzyme for endogenous nitric oxide (NO), and it converts GTP to cyclic GMP (guanosine 3’,5’-cyclic monophosphate) as part of a cascade that results in physiological processes such as smooth muscle relaxation ...
Masaki Nakane +5 more
doaj
Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad
Journal of Cardiovascular Pharmacology, 2015 : In a number of isolated blood vessel types, hypoxia causes an acute contraction that is dependent on the presence of nitric oxide and activation of soluble guanylyl cyclase.
Yuansheng Gao +3 more
semanticscholar +1 more source
The integrated model of cAMP-dependent DNA expression reveals an inverse relationship between cancer and neurodegeneration [PDF]
arXiv, 2016 The model for cAMP-dependent synaptic plasticity relates the characterization of a noradrenaline-stimulated adenylyl cyclase with DNA unzipping. Specific proteins condition cAMP insertion in specific sites of the DNA structure to direct cellular and synaptic differentiation in brain tissues, also providing coding. Metabolic-dependent ATP binding of Mg2+
arxiv
Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling [PDF]
, 2015 Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2.
Bruder-Nascimento, Thiago +7 more
core +3 more sources
Develop machine learning based predictive models for engineering protein solubility [PDF]
arXiv, 2018 Protein activity is a significant characteristic for recombinant proteins which can be used as biocatalysts. High activity of proteins reduces the cost of biocatalysts. A model that can predict protein activity from amino acid sequence is highly desired, as it aids experimental improvement of proteins.
arxiv
American Journal of Physiology. Heart and Circulatory Physiology, 2015 Impaired nitric oxide (NO), soluble guanylyl cyclase (sGC), and cyclic guanosine monophosphate (cGMP) signaling (NO-sGC-cGMP) has been implicated in the pathogenesis of diabetic vascular dysfunction.
S. Goulopoulou +5 more
semanticscholar +1 more source
Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion [PDF]
, 2011 Background Integrin activation in response to inside-out signaling serves as the basis for rapid leukocyte arrest on endothelium, migration, and mobilization of immune cells.
Chigaev, Alexandre +2 more
core +3 more sources
Lie algebra F-normalisers are intravariant [PDF]
arXiv, 2007 Let F be a saturated formation of soluble Lie algebras and let U be an F-normaliser of the soluble Lie algebra L. Then U is intravariant in L.
arxiv