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Soluble guanylyl cyclase: more secrets revealed
Cellular Signalling, 2005Guanylyl cyclases (GCs) are enzymes that convert guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophosphate (cGMP). The second messenger cGMP participates in signaling by (1) stimulating the activity of kinases that belong to the protein kinase G family, (2) altering the conductance of cGMP-gated ion channels and (3) changing the activity ...
Anastasia, Pyriochou +1 more
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Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells
Biochemical and Biophysical Research Communications, 2014Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and generates the second messenger cyclic GMP (cGMP). Recently, purified sGC α1β1 has been shown to additionally generate the cyclic pyrimidine nucleotides cCMP and cUMP. However, since cyclic pyrimidine nucleotide formation occurred only the presence of Mn(2+) but not Mg(2+), the ...
Heike, Bähre +4 more
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Hemoglobin mediated nitrite activation of soluble guanylyl cyclase
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2005Nitrite has long been known to be vasoactive when present at large concentrations but it was thought to be inactive under physiological conditions. Surprisingly, we have recently shown that supraphysiological and near physiological concentrations of nitrite cause vasodilation in the human circulation.
Anne, Jeffers +6 more
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Soluble Guanylyl Cyclase: The Nitric Oxide Receptor
2005Soluble guanylyl cyclase is recognized as the most sensitive physiologic receptor for nitric oxide. Binding of nitric oxide to the heme moiety of the cyclase induces its capacity to synthesize the second messenger cGMP. Although the changes in the state of the heme moiety upon exposure of enzyme to NO and its correlation to the stimulation of sGC ...
Emil, Martin +3 more
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Regulation of nitric oxide and soluble guanylyl cyclase
Brain Research Bulletin, 2004Since the discoveries that have verified nitric oxide (NO) as an endogenously produced cell signaling molecule, research surrounding its production and mechanisms of action have been studied at an exponentially increasing rate. NO is produced by a family of enzymes termed the NO synthases (NOS), which are regulated independently by various stimuli ...
Joshua S, Krumenacker +2 more
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1996
In addition to phospholipases, NO synthases and adenylyl cyclases which synthesize lipid second messengers, NO and cAMP respectively, guanylyl cyclases are also capable of production of the potent transducer molecule cyclic GMP.
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In addition to phospholipases, NO synthases and adenylyl cyclases which synthesize lipid second messengers, NO and cAMP respectively, guanylyl cyclases are also capable of production of the potent transducer molecule cyclic GMP.
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Enzymology of Soluble Guanylyl Cyclase
2000Soluble guanylyl cyclase (sGC) probably represents the most important receptor for nitric oxide (NO) as a signalling molecule (Fig. 1). The enzyme catalyses the conversion of guanosine triphosphate (GTP) into guanosine cyclic monophosphate (cGMP). Activation of sGC by NO leads to an enormous stimulation of cGMP production, yielding an up to 400-fold ...
D. Koesling, A. Friebe
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Soluble guanylyl cyclase during postnatal porcine pulmonary maturation
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005The nitric oxide (NO)/cGMP pathway plays a key role in the regulation of pulmonary vascular tone during the transition from the fetal to the neonatal circulation, and it is impaired in pathophysiological conditions such as pulmonary hypertension. In the present study, we have analyzed the changes in the function and expression of soluble guanylyl ...
Laura, Moreno +7 more
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Functions of Conserved Cysteines of Soluble Guanylyl Cyclase
Biochemistry, 1997Soluble guanylyl cyclase (sGC), a heme-containing heterodimeric enzyme, is stimulated by NO and catalyzes the formation of the intracellular signaling molecule cGMP. Cysteine residues of sGC have been considered to be important as they were thought to play a significant role in the regulation of the enzyme.
A, Friebe +5 more
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