Instability in a coiled-coil signaling helix is conserved for signal transduction in soluble guanylyl cyclase. [PDF]
Protein Sci, 2019 How nitric oxide (NO) activates its primary receptor, α1/β1 soluble guanylyl cyclase (sGC or GC‐1), remains unknown. Likewise, how stimulatory compounds enhance sGC activity is poorly understood, hampering development of new treatments for cardiovascular
Weichsel A +4 more
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Carbon monoxide signaling and soluble guanylyl cyclase: Facts, myths, and intriguing possibilities. [PDF]
Biochem Pharmacol, 2022 Lu W, Yang X, Wang B.
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Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation. [PDF]
Sci RepPeripheral neurotoxicity is a dose-limiting adverse reaction of primary frontline chemotherapeutic agents, including vincristine. Neuropathy can be so disabling that patients drop out of potentially curative therapy, negatively impacting cancer prognosis.
Utkina-Sosunova I +15 more
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Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer. [PDF]
Int J Mol SciSince the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase
Pino MTL +3 more
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Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism. [PDF]
J Biol Chem, 2019 The enzyme soluble guanylyl cyclase (sGC) is a heterodimer composed of an α subunit and a heme-containing β subunit. It participates in signaling by generating cGMP in response to nitric oxide (NO).
Dai Y +4 more
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Reduction of soluble guanylyl cyclase expression in asthma [PDF]
BMC Pharmacology, 2005 Soluble guanylyl cyclase (sGC) is a ubiquitously expressed enzyme that is highly expressed in the lung. Stimulation of sGC by nitric oxide (NO) increases the conversion of GTP to cGMP, thereby, causing airway smooth muscle relaxation. To determine whether sGC expression is reduced in an animal model of inflammatory airway disease and, therefore ...
Andreas Papapetropoulos +4 more
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Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines. [PDF]
Sci Rep, 2019 Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits by increasing α1 and decreasing both β1 expression and enzymatic ...
Ronchetti SA +6 more
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Scientific Reports, 2017 Hypertension is a dominating risk factor for cardiovascular disease. To characterize the genomic response to hypertension, we administered vehicle or angiotensin II to mice and performed gene expression analyses.
Catarina Rippe +7 more
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Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase.
FASEB J, 2019 Myoglobin (Mb) maturation involves heme incorporation as a final step. We investigated a role for heat shock protein (hsp) 90 in Mb maturation in C2C12 skeletal muscle myoblasts and cell lines.
Ghosh A, Dai Y, Biswas P, Stuehr DJ.
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Nephroprotective effects of the soluble guanylyl cyclase stimulator, riociguat in doxorubicin-induced acute kidney injury in rats. [PDF]
Toxicol RepThis study aimed to investigate the potential protective effects of riociguat, a soluble guanylyl cyclase (sGC) stimulator, on kidney function and structure in rats with acute kidney injury (AKI) induced by the chemotherapeutic drug doxorubicin (DX ...
Al-Maskari R +4 more
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