PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
Communications Biology, 2022 PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells.
Staffan Hildebrand +5 more
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Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor. [PDF]
PLoS ONE, 2013 Guanylyl cyclases (GCs) regulate many physiological processes by catalyzing the synthesis of the second messenger cGMP. The GC family consists of seven particulate GCs (pGCs) and a nitric oxide-activated soluble GC (sGC).
Kerstin Y Beste +7 more
doaj +1 more source
Redox regulation of soluble guanylyl cyclase. [PDF]
Nitric Oxide, 2018 The nitric oxide/soluble guanylyl cyclase (NO-sGC) signaling pathway regulates the cardiovascular, neuronal, and gastrointestinal systems. Impaired sGC signaling can result in disease and system-wide organ failure. This review seeks to examine the redox control of sGC through heme and cysteine regulation while discussing therapeutic drugs that target ...
Shah RC +4 more
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Scientific Reports, 2023 Chronic smoking causes dysfunction of vascular endothelial cells, evident as a reduction of flow-mediated dilation in smokers, but the role of nicotine is still controversial.
Gerald Wölkart +5 more
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Functional Domains of Soluble Guanylyl Cyclase [PDF]
Journal of Biological Chemistry, 1995 Soluble guanylyl cyclase is a heterodimer consisting of an alpha and beta subunit and stimulation occurs upon binding of NO to a prosthetic group. Little is known about the localization of catalytic and regulatory domains within the subunits of soluble guanylyl cyclase. We used deletion mutagenesis to identify the regions of alpha 1 and beta 1 subunits
B, Wedel +5 more
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Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism [PDF]
J Biol Chem, 2019 Kenneth Childers +5 more
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Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose. [PDF]
PLoS ONE, 2012 The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase α(1)β(1) synthesize the cyclic pyrimidine nucleotide cCMP.
Andreas Hammerschmidt +9 more
doaj +1 more source
Nucleotidyl cyclase activity of recombinant soluble guanylyl cyclase [PDF]
BMC Pharmacology, 2009 The ubiquitously expressed soluble guanylyl cyclase(sGC) converts guanosine 5'-triphosphate (GTP) to gua-nosine 3':5'-cyclic monophosphate (cGMP). The het-erodimeric protein is activated by nitric oxide (NO). sGCplays a key role in the regulation of vascular tone and neu-rotransmission.
Rauch, Kerstin +3 more
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Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction. [PDF]
PLoS ONE, 2015 Soluble guanylyl cyclase (sGC) is a heterodimeric nitric oxide (NO) receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system.
Erin J Heckler +5 more
doaj +1 more source
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase. [PDF]
J Biol Chem, 2021 Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an amplifier in NO-driven biological signaling cascades. Because sGC helps regulate the cardiovascular, neuronal, and gastrointestinal systems through its cGMP production ...
Stuehr DJ, Misra S, Dai Y, Ghosh A.
europepmc +4 more sources