Results 31 to 40 of about 7,812 (188)
Soluble guanylyl cyclase activation promotes angiogenesis [PDF]
BMC Pharmacology, 2005 Two commonly accepted features of soluble guanylyl cyclase (sGC): its lack of "partners" and its exclusive-cytoplasmic localization were recently challenged. Several proteins that bind directly to sGC have now been identified. The molecular chaperone Hsp70 is one of these sGCinteracting proteins.
Pyriochou, Anastasia +3 more
openaire +3 more sources
Expression of soluble guanylyl cyclase [PDF]
FEBS Letters, 1990 Purified soluble guanylyl cyclase consists of two subunits (70 and 73 kDa) whose primary structures were recently determined. The availability of cDNA clones coding for either subunit allowed to study the question of the functional roles of the two subunits in expression experiments.
Christian Harteneck +4 more
openalex +4 more sources
Cardiovascular Diabetology, 2012 Background Adiposity greatly increases the risk of atherothrombotic events, a pathological condition where a chronic state of oxidative stress is reported to play a major role.
Monteiro Priscila F +7 more
doaj +1 more source
β-Amyloid Peptides Decrease Soluble Guanylyl Cyclase Expression in Astroglial Cells
Neurobiology of Disease, 2002 In astroglial cells β-amyloid peptides (βA) induce a reactive phenotype and increase expression of NO synthase. Here we show that treatment of rat brain astrocytes with βA decreases their capacity to accumulate cyclic GMP (cGMP) in response to NO as a ...
Marı́a Antonia Baltrons +3 more
doaj +1 more source
Soluble Guanylyl Cyclase Activation Promotes Angiogenesis
The Journal of Pharmacology and Experimental Therapeutics, 2006 Soluble guanylyl cyclase (sGC) is a cGMP-generating enzyme carrying a heme prosthetic group that functions as a nitric oxide (NO) sensor. sGC is present in most cells types, including the vascular endothelium, where its biological functions remain largely unexplored.
Pyriochou, Anastasia +6 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2004 The pharmacological mechanisms of a synthetic compound 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) in preventing smooth muscle cell proliferation remains to be elucidated.
Chieh-Hsi Wu +4 more
doaj +1 more source
Effect of D4 Dopamine Receptor on Na+-K+-ATPase Activity in Renal Proximal Tubule Cells
Cardiology Discovery, 2023 Objective:. Dopamine, via its receptors, plays a vital role in the maintenance of blood pressure by modulating renal sodium transport. However, the role of the D4 dopamine receptor (D4 receptor) in renal proximal tubules (PRTs) is still unclear.
Duofen He +6 more
doaj +1 more source
A peptide against soluble guanylyl cyclase α1: a new approach to treating prostate cancer. [PDF]
PLoS ONE, 2013 Among the many identified androgen-regulated genes, sGCα1 (soluble guanylyl cyclase α1) appears to play a pivotal role in mediating the pro-cancer effects of androgens and androgen receptor.
Shuai Gao +4 more
doaj +1 more source
Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi
Balkan Medical Journal, 2016 Background: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the more post-ERCP complications ...
Erol Çakmak +6 more
doaj +1 more source
Effects of Oxygen on Perioperative Vascular Function: A Randomized Clinical Trial
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Vascular dysfunction contributes to postoperative organ injury. Exposure to high concentrations of oxygen during surgery is common and may impair vascular function.
Marcos G. Lopez +8 more
doaj +1 more source