Identification of proteins associated with soluble guanylyl cyclase [PDF]
BMC News and views, 2003 Werner Müller‐Esterl +3 more
openalex +2 more sources
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice
British Journal of Pharmacology, 2023 Alcohol abuse has been associated with erectile dysfunction (ED), but the implicated molecular mechanisms are unresolved. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED.
M. A. Olivencia +8 more
semanticscholar +1 more source
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
Communications Biology, 2022 PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells.
Staffan Hildebrand +5 more
doaj +1 more source
Structure-function analysis of soluble guanylyl cyclase: [PDF]
BMC News and views, 2003 Fu‐Jung Chang +4 more
openalex +2 more sources
Regulation of soluble guanylyl cyclase by phosphorylation [PDF]
BMC Pharmacology, 2009 Results In vitro kinase assays revealed that the α1, but not the β1, subunit of sGC is a PKG substrate and that the phosphorylation site is located within the first 360 residues of the α1. A constitutively active form of PKG stimulated incorporation of 32P into the α1 subunit in vivo.
Zhou, Zongmin +5 more
openaire +4 more sources
Bioactive food components and their inhibitory actions in multiple platelet pathways
Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022 A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described. Abstract In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis ...
Diptimayee Das +7 more
wiley +1 more source
Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor. [PDF]
PLoS ONE, 2013 Guanylyl cyclases (GCs) regulate many physiological processes by catalyzing the synthesis of the second messenger cGMP. The GC family consists of seven particulate GCs (pGCs) and a nitric oxide-activated soluble GC (sGC).
Kerstin Y Beste +7 more
doaj +1 more source
Functional Domains of Soluble Guanylyl Cyclase [PDF]
Journal of Biological Chemistry, 1995 Soluble guanylyl cyclase is a heterodimer consisting of an alpha and beta subunit and stimulation occurs upon binding of NO to a prosthetic group. Little is known about the localization of catalytic and regulatory domains within the subunits of soluble guanylyl cyclase. We used deletion mutagenesis to identify the regions of alpha 1 and beta 1 subunits
Andreas Friebe +5 more
openaire +2 more sources
Scientific Reports, 2023 Chronic smoking causes dysfunction of vascular endothelial cells, evident as a reduction of flow-mediated dilation in smokers, but the role of nicotine is still controversial.
Gerald Wölkart +5 more
doaj +1 more source
The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy. [PDF]
PLoS ONE, 2012 Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences of the soluble guanylyl cyclase (sGC) activator BAY 58-2667 on cardiac remodeling, independent of changes in hemodynamic load, has not been ...
Jennifer C Irvine +7 more
doaj +1 more source