Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation. [PDF]
PLoS ONE, 2012 New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention for the treatment of cardiovascular disorders, eliciting cGMP ...
Eliane Q Lin +9 more
doaj +1 more source
Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1. [PDF]
, 2014 Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are expressed in the brain and retina where they transduce calcium signals and are genetically linked to degenerative diseases.
Ames, James B +2 more
core +2 more sources
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
Effect of D4 Dopamine Receptor on Na+-K+-ATPase Activity in Renal Proximal Tubule Cells
Cardiology Discovery, 2023 Objective:. Dopamine, via its receptors, plays a vital role in the maintenance of blood pressure by modulating renal sodium transport. However, the role of the D4 dopamine receptor (D4 receptor) in renal proximal tubules (PRTs) is still unclear.
Duofen He +6 more
doaj +1 more source
Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]
, 2006 Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Garthwaite, J, Hopper, RA
core +1 more source
A peptide against soluble guanylyl cyclase α1: a new approach to treating prostate cancer. [PDF]
PLoS ONE, 2013 Among the many identified androgen-regulated genes, sGCα1 (soluble guanylyl cyclase α1) appears to play a pivotal role in mediating the pro-cancer effects of androgens and androgen receptor.
Shuai Gao +4 more
doaj +1 more source
Polycyclic, metabelian or soluble of type (FP)$_{\infty}$ groups with boolean algebra of rational sets and biautomatic soluble groups are virtually abelian [PDF]
Glasgow Math. J. Jan. 2018, Vol. 60, Issue 1, 209-218, 2015 Let $G$ be a polycyclic, metabelian or soluble of type (FP)$_{\infty}$ group such that the class $Rat(G)$ of all rational subsets of $G$ is a boolean algebra. Then $G$ is virtually abelian. Every soluble biautomatic group is virtually abelian.
arxiv +1 more source
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice [PDF]
, 2015 Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC.
Bloch, Kenneth D +17 more
core +1 more source
On the proportions of soluble forms in some families of locally soluble binary quartic forms [PDF]
arXiv, 2023 An integral binary quartic form is said to be locally soluble (resp. soluble) if the corresponding genus one curve has a rational point over $\mathbb{Q}_v$ for every place $v$ of $\mathbb{Q}$ (resp. over $\mathbb{Q}$). We consider the proportion of soluble integral binary quartic forms in locally soluble forms.
arxiv
Regulation of nitric oxide signaling by formation of a distal receptor-ligand complex. [PDF]
, 2017 The binding of nitric oxide (NO) to the heme cofactor of heme-nitric oxide/oxygen binding (H-NOX) proteins can lead to the dissociation of the heme-ligating histidine residue and yield a five-coordinate nitrosyl complex, an important step for NO ...
Britt, R David +5 more
core +1 more source