Results 51 to 60 of about 7,812 (188)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells

Frontiers in Pharmacology, 2012
BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs).
Shaquria P Adderley, Chintamani N Joshi, Danielle N Martin, David Anthony Tulis   +3 more
doaj   +1 more source

Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. [PDF]

PLoS ONE, 2014
Nitric oxide (NO) is involved in retinal signal processing, but its cellular actions are only partly understood. An established source of retinal NO are NOACs, a group of nNOS-expressing amacrine cells which signal onto bipolar, other amacrine and ...
Alex H Vielma, Adolfo Agurto, Joaquín Valdés, Adrián G Palacios, Oliver Schmachtenberg   +4 more
doaj   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle

Journal of Pharmacological Sciences, 2007
We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 – 10 mM had no effect on the tone of those preparations without precontraction.
Satoko Kubo, Ichiko Doe, Yuko Kurokawa, Atsufumi Kawabata   +3 more
doaj   +1 more source

A physiologically relevant role for NO stored in vascular smooth muscle cells: A novel theory of vascular NO signaling

Redox Biology, 2022
S-nitrosothiols (SNO), dinitrosyl iron complexes (DNIC), and nitroglycerine (NTG) dilate vessels via activation of soluble guanylyl cyclase (sGC) in vascular smooth muscle cells.
Taiming Liu, Hobe Schroeder, Gordon G. Power, Arlin B. Blood   +3 more
doaj   +1 more source

Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation [PDF]

, 2021
Carina Mauersberger, Hendrik B. Sager, Jana Wobst, Tan An Dang, Laura Lambrecht, Simon Koplev, Marlène Stroth, Noomen Bettaga, Jens Schlossmann, Frank Wunder, Andreas Friebe, Johan Björkegren, Lisa Dietz, Peter Sandner, Oliver Soehnlein, Heribert Schunkert, Thorsten Kessler   +16 more
openalex   +1 more source

Structure/function of the soluble guanylyl cyclase catalytic domain. [PDF]

Nitric Oxide, 2018
Soluble guanylyl cyclase (GC-1) is the primary receptor of nitric oxide (NO) in smooth muscle cells and maintains vascular function by inducing vasorelaxation in nearby blood vessels. GC-1 converts guanosine 5'-triphosphate (GTP) into cyclic guanosine 3',5'-monophosphate (cGMP), which acts as a second messenger to improve blood flow.
Childers KC, Garcin ED.
europepmc   +3 more sources

No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Sepiapterin and its major metabolite 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) bind to distinct variants of phenylalanine hydroxylase (PAH), which converts excess phenylalanine to tyrosine, thereby stabilizing, enhancing, and prolonging PAH activity.
Lan Gao, Hongqi Xue, Borje Darpo, Kimberly Ingalls, Diksha Kaushik, Neil Smith, Ronald Kong, Lee Golden   +7 more
wiley   +1 more source