Results 61 to 70 of about 30,038 (314)

Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi

Balkan Medical Journal, 2016
Background: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the more post-ERCP complications ...
Erol Çakmak, Özlem Yönem, Bülent Saraç, Mesut Parlak, Cumali Çelik, Hilmi Ataseven, İhsan Bağcivan   +6 more
doaj   +1 more source

The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective

International Journal of Molecular Sciences, 2018
Chronic Kidney Disease (CKD) is a highly prevalent disease with a substantial medical need for new and more efficacious treatments. The Nitric Oxide (NO), soluble guanylyl cyclase (sGC), cyclic guanosine monophosphate (cGMP) signaling cascade regulates ...
S. Krishnan, Jan R. Kraehling, F. Eitner, A. Bénardeau, P. Sandner   +4 more
semanticscholar   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +2 more sources

Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone

Acta Pharmaceutica Sinica B, 2017
The natural compound thymoquinone, extracted from Nigella sativa (black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endothelium-independent vasodilator effects in isolated rat aortae and ...
Charlotte Detremmerie, Paul M. Vanhoutte, Susan Leung   +2 more
doaj   +1 more source

Mechanisms of Action and Targets of Nitric Oxide in the Oculomotor System [PDF]

, 1998
Nitric oxide (NO) production by neurons in the prepositus hypoglossi (PH) nucleus is necessary for the normal performance of eye movements in alert animals.
Escudero González, Miguel, Estrada Cerquera, Carmen, Moreno López, Bernardo   +2 more
core   +1 more source

Modulation of sensory information processing by a neuroglobin in C. elegans [PDF]

, 2016
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. We show that in the C. elegans URX O2 sensing neurons two putative molecular O2 sensors, a neuroglobin and O2-binding soluble guanylate cyclases, work antagonistically to sculpt a slowly ...
arxiv   +1 more source

Finite groups whose maximal subgroups have only soluble proper subgroups [PDF]

arXiv, 2021
We give a description of a finite group whose maximal subgroups possess only soluble proper subgroups, which implies the answer to the well-known question on composition factors of finite groups, whose second maximal subgroups are soluble.
arxiv  

Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats

Frontiers in Physiology, 2021
Closure of the ductus arteriosus (DA) involves vasoconstriction and vascular remodeling. Cinaciguat, a soluble guanylyl cyclase (sGC) activator, was reported with vasodilatory and anti-remodeling effects on pulmonary hypertensive vessels.
Yu-Chi Hung, Yu-Chi Hung, Yi-Ching Liu, Bin-Nan Wu, Bin-Nan Wu, Bin-Nan Wu, Jwu-Lai Yeh, Jwu-Lai Yeh, Jwu-Lai Yeh, Jwu-Lai Yeh, Jong-Hau Hsu, Jong-Hau Hsu   +11 more
doaj   +1 more source

Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor.

Antioxidants and Redox Signaling, 2017
SIGNIFICANCE Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) and is central to the physiology of blood pressure regulation, wound healing, memory formation, and other key physiological activities.
W. Montfort, Jessica A. Wales, A. Weichsel   +2 more
semanticscholar   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources