Results 231 to 240 of about 82,478 (265)

Tissue Expression and Plasma Soluble PD-L1 Levels in Patients With Endometrial Cancer

Anticancer Research
The prognostic role of tissue PD-L1 expression in endometrial cancer (EC) remains controversial. Moreover, its value in guiding anti-PD1/PD-L1 immunotherapy is questionable. The eventual role of soluble PD-L1 (sPD-L1), released by cancer tissue and circulating immune cells, is largely unexplored.In this pilot study, we investigated the expression of PD-
Emmanuel, Kontomanolis, Antonios, Koutras, Achilleas G, Mitrakas, Grigorios, Trypsianis, Konstantinos, Nikolettos, Panagiotis, Tsikouras, Nikolaos, Nikolettos, Alexandra, Giatromanolaki, Michael, Koukourakis   +8 more
openaire   +3 more sources

PD-L1 expression in tumor lesions and soluble PD-L1 serum levels in patients with breast cancer: TNBC versus TPBC

Breast Disease, 2021
BACKGROUND: Block of programmed cell death protein 1 (PD-1) interaction with its ligand, PD-L1, enhances anti-tumor activity. OBJECTIVES: We aimed to assess the association between PD-L1 expression in tumor cells and CD8+ tumor infiltrating T cells (TILs) as well as soluble (s)PD-L1 serum levels in patients with triple negative breast cancer (TNBC ...
Parvaneh, Yazdanpanah, Ali, Alavianmehr, Abbas, Ghaderi, Ahmad, Monabati, Mehdi, Montazer, Kamran, Tahmasbi, Shirin, Farjadian   +6 more
openaire   +2 more sources

Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma

Oncology, 2021
<b><i>Introduction:</i></b> We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens.
Tadashi Shiraishi, Takeshi Toyozumi, Haruhito Sakata, Kentaro Murakami, Masayuki Kano, Yasunori Matsumoto, Masaya Yokoyama, Koichiro Okada, Toshiki Kamata, Takahiro Ryuzaki, Kazuya Kinoshita, Soichiro Hirasawa, Hisahiro Matsubara   +12 more
openaire   +2 more sources

Soluble PD-L1 and Circulating CD8+PD-1+ and NK Cells Enclose a Prognostic and Predictive Immune Effector Score in Immunotherapy Treated NSCLC patients.

Lung Cancer, 2020
INTRODUCTION Upfront criteria to foresee immune checkpoint inhibitors (ICIs) efficacy are far from being identified. Thus, we integrated blood descriptors of pro-inflammatory/immunosuppressive or effective anti-tumor response to non-invasively define ...
G. Mazzaschi, R. Minari, A. Zecca, A. Cavazzoni, V. Ferri, C. Mori, A. Squadrilli, P. Bordi, S. Buti, M. Bersanelli, A. Leonetti, A. Cosenza, L. Ferri, E. Rapacchi, Gabriele Missale, P. Petronini, Federico Quaini, Marcello Tiseo   +17 more
semanticscholar   +1 more source

Enzyme-catalyzed electrochemical aptasensor for ultrasensitive detection of soluble PD-L1 in breast cancer based on decorated covalent organic frameworks and carbon nanotubes.

Analytica Chimica Acta, 2023
BACKGROUND Soluble programmed death-ligand 1 (sPD-L1) is critically involved in breast cancer recurrence and metastasis. However, the clinical application of highly sensitive sPD-L1 assays remains a challenge due to its low abundance in peripheral blood.
Yue Zhang, Shuyi Chen, Jie Ma, Xiaobin Zhou, Xinchen Sun, Hongyun Jing, Mei Lin, Chenglin Zhou   +7 more
semanticscholar   +1 more source

A near-infrared fluorescence-enhancing plasmonic biosensing microarray identifies soluble PD-L1 and ICAM-1 as predictive checkpoint biomarkers for cancer immunotherapy.

Biosensors & bioelectronics, 2023
Sensitive and accurate biomarker-driven assay guidance has been widely adopted to identify responsive patients for immune checkpoint blockade (ICB) therapy to impede disease progression and extend survival.
Zhi-dong Lin, Mengyao Liu, W. Xing, Feng‐Hua Wang, Hongxia Zhang, Xiaoli Wei, H. Schmitthenner, Xi Xie, X. Xia, Jiang Yang   +9 more
semanticscholar   +1 more source

Characteristics of Soluble PD‐L1 and PD‐1 Expression and Their Correlations With Immune Status and Prognosis in Advanced Lung Cancer

Asia-Pacific Journal of Clinical Oncology
Our study aims to evaluate the characteristics of serum soluble PD‐1 (sPD‐1) and soluble PD‐L1 (sPD‐L1) levels and their correlations with immune status and prognosis in advanced lung cancer patients.
Ran Li, Hongge Liang, Ying Shang, Zhengwu Yang, Keqiang Wang, Donghong Yang, J. Bao, Wen Xi, De-xun Zhou, Wentao Ni, Zhancheng Gao, X. Mu   +11 more
semanticscholar   +1 more source

Soluble PD-L1 (sPD-L1) as a biomarker of durable response and survival in patients with advanced non-small cell lung cancer (NSCLC) treated with first-line immune checkpoint inhibitors (ICIs)

Cancer Immunology and Immunotherapy
There is a need for biomarkers to predict response and survival to immune checkpoint inhibitors (ICIs) in patients with advanced non-small cell lung cancer (NSCLC). Soluble PD-L1 (sPD-L1) has shown biomarker potential.
A.E. Costantini, P. Takam Kamga, E. Pons-Tostivint, Delphine Fradin, J-F. Emile, E. Giroux-Leprieur   +5 more
semanticscholar   +1 more source

Soluble PD-L1 and Serum Vascular Endothelial Growth Factor-B May Independently Predict Prognosis in Patients with Advanced Non-Small Cell Lung Cancer Treated with Pembrolizumab

Cancers
Simple Summary In this prospective cohort study, the prognostic and predictive value of baseline and post-treatment levels of serum VEGF-A, VEGF-B, sPD-1, and sPD-L1 were investigated in 55 advanced NSCLC patients treated with immune checkpoint ...
E. Kokkotou, D. Grapsa, A. Papadopoulou, S. Gaitanakis, P. Bakakos, G. Poulakou, P. Moutsatsou, K. Syrigos   +7 more
semanticscholar   +1 more source

Soluble PD-L1 as a marker of progressive disease on nivolumab in kidney cancer.

Journal of Clinical Oncology, 2020
746 Background: Higher levels of soluble PD-L1 (sPD-L1) are associated with poor prognosis in patients with solid tumors including in renal cell carcinoma (RCC). Here we have tested whether in patients with advanced RCC, sPD-L1 levels are associated with PD-L1 expression on tumor tissue or with clinical outcomes on PD-1 blockade.
Kathleen Margaret Mahoney, Petra B. Ross-Macdonald, Sachet A. Shukla, David A. Braun, Linan Song, Eliseo Veras, Megan Wind-Rotolo, Eliezer Mendel Van Allen, David F. McDermott, F. Stephen Hodi, Toni K. Choueiri, Gordon J. Freeman   +11 more
openaire   +1 more source