Results 71 to 80 of about 82,478 (265)

The Role of Soluble Immune Checkpoint in SARS-CoV-2 Iraqi Patients

The Iraqi Journal of Medical Sciences
Background: A novel coronavirus causing corona virus 2019 (COVID-19) disease, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a serious cause of respiratory failure, cytokine release syndrome or myocarditis.
Anmar L. Talib, Haider S. Kadhim
doaj   +6 more sources

Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation

JCI Insight, 2021
Immune checkpoint therapy targeting the PD-1/PD-L1 axis is a potentially novel development in anticancer therapy and has been applied to clinical medicine.
Ray Sagawa, S. Sakata, B. Gong, Yosuke Seto, Ai Takemoto, S. Takagi, H. Ninomiya, N. Yanagitani, M. Nakao, M. Mun, K. Uchibori, M. Nishio, Y. Miyazaki, Y. Shiraishi, S. Ogawa, K. Kataoka, Naoya Fujita, K. Takeuchi, Ryohei Katayama   +18 more
semanticscholar   +1 more source

Soluble PD-L1 Expression After Intravenous Treatment of Cancer Patients With Selenite in Phase I Clinical Trial

Frontiers in Oncology, 2022
A high expression level of programmed death-ligand 1 (PD-L1) is observed in different types of cancers (particularly lung cancer). Soluble (s)PD-L1 may be used as a prognostic marker and a target for anti-cancer immunity, as well as, predicting gene ...
Ali Razaghi, Ladan Mansouri, Ola Brodin, Ola Brodin, Mikael Björnstedt, Joachim Lundahl   +5 more
doaj   +1 more source

Prognostic Value of Serum Soluble PD-L1 in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab

Anticancer Research, 2023
Background/Aim: Increasing availability of effective treatment options for metastatic renal cell carcinoma (mRCC) has highlighted the importance of identifying predictors of treatment response.
N. Wakita, N. Hinata, Yukari Bando, T. Hara, T. Terakawa, J. Furukawa, Y. Nakano, M. Fujisawa   +7 more
semanticscholar   +1 more source

Characterization and dynamics of the soluble immunological microenvironment in melanoma patients undergoing radiotherapy

Radiation Oncology, 2022
Highlights Malignant melanoma patients reveal a characteristic and distinct immunological pattern. Elevated levels of soluble PD-L1 induced by previous immunotherapy were found.
Michael Oertel, Katrin Borrmann, Andrea Baehr, Hans Theodor Eich, Burkhard Greve   +4 more
doaj   +1 more source

PD-L1⁺ HIV virions are functionally active and contribute to Tfh cell functional impairment in vitro.

, 2022
PD-1/NFAT reporter Jurkat cells were stimulated with anti-CD3/CD28 mAbs and cultured in presence of recombinant PD-L1 protein (rPD-L1), PDL1high or PD-L1low HIV virions.
Riddhima Banga (634344), Matthias Cavassini (146654), Laurent Perez (3458786), Pauline Nortier (13001930), Francesco Andrea Procopio (7022861), Craig Fenwick (1792990), Andrea Mastrangelo (11594374), Jean Daraspe (5574758), Matthieu Perreau (268148), Olivia Munoz (7022867), Rachel Schelling (13001927), Khalid Ohmiti (430647)   +11 more
core   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

Liquid-Based Diagnostic Panels for Prostate Cancer: The Synergistic Role of Soluble PD-L1, PD-1, and mRNA Biomarkers

International Journal of Molecular Sciences
This study aimed to evaluate the diagnostic potential of soluble Programmed Death Ligand 1 (sPD-L1) and Programmed Death 1 (sPD-1) molecules in plasma, along with urinary mRNA biomarkers—Prostate-Specific Membrane Antigen (PSMA), Prostate Cancer Antigen ...
Margarita Žvirblė, I. Vaicekauskaitė, Žilvinas Survila, P. Bosas, N. Dobrovolskienė, A. Mlynska, R. Sabaliauskaitė, V. Pašukonienė   +7 more
semanticscholar   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Soluble PD-L1 in blood correlates positively with neutrophil and negatively with lymphocyte mRNA markers and implies adverse sepsis outcome

Immunologic research, 2022
Sepsis causes a myriad of immunological reactions that result in life-threatening alterations in the human body. Immunosuppression in sepsis is partly attributed to the programmed death receptor (PD-1) and its associated ligand (PD-L1) via the regulation
Marcus Derigs, H. Heers, S. Lingelbach, R. Hofmann, J. Hänze   +4 more
semanticscholar   +1 more source