Results 91 to 100 of about 4,013,036 (260)

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [PDF]

, 2010
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss.
Fuhrmann Martin, Kretzschmar Hans, Ochs, Simon M., Herms Jochen, Simon M Ochs, Burgold Steffen, Jochen Herms, Frank M LaFerla, Burgold, Steffen, Herms, Jochen, Hans Kretzschmar, Gerda Mitteregger, Fuhrmann, Martin, Kretzschmar, Hans, Ochs Simon M., Frank M. Laferla, LaFerla Frank M., Hoffmann, Nadine, LaFerla, Frank M., Bittner, Tobias, Bittner Tobias, Mitteregger, Gerda, Nadine Hoffmann, Simon M. Ochs, Martin Fuhrmann, Tobias Bittner, Hoffmann Nadine, Steffen Burgold, Mitteregger Gerda   +28 more
core   +2 more sources

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Heterologous expression and site-directed mutagenesis of soluble methane monoxygenase [PDF]

The purpose of this investigation was to study the heterologous expression of soluble methane monooxygenase (sMMO) genes from Methylococcus capsulatus (Bath) and Methylosinus trichosporium OB3b.
Lloyd, John S.
core  

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown [PDF]

, 2010
Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in non ...
Romero, Ignacio, Deiß Annika, Deiß, Annika, Buttmann, Mathias, Weksler Babette, Rieckmann, Peter, Ignacio Romero, Mathias Buttmann, Prochaska, Jürgen, Couraud, Pierre-Olivier, Jürgen Prochaska, Haarmann, Axel, Peter Rieckmann, Buttmann Mathias, Weksler, Babette, Axel Haarmann, Stoll, Guido, Najbauer, Joseph, Pierre-Olivier Couraud, Annika Deiss, Couraud Pierre-Olivier, Prochaska, Juergen, Stoll Guido, Guido Stoll, Förch, Christian, Romero Ignacio, Foerch, Christian, Prochaska Jürgen, Christian Foerch, Rieckmann Peter, Babette Weksler, Foerch Christian, Haarmann Axel   +32 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Heat-soluble property of RvLEAM protein.

, 2015
Heat-solubility of RvLEAM protein is shown using either RvLEAM-induced bacterial lysate (a) or purified RvLEAM protein (b). ‘S’ indicates starting sample before heat treatment. After heat treatment, the proteins were separated into a soluble fraction (HS)
Toshiaki Katayama (13875), Kazuharu Arakawa (62392), Takekazu Kunieda (25271), Atsushi Toyoda (24202), Daiki D. Horikawa (140708), Sae Tanaka (140703), Junko Tanaka (130314), Yoshihiro Miwa (692029), Takeo Kubo (25272)   +8 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Vertical Distribution of Soluble Organic Nitrogen Composition in Paddy Soils: Effects of Chinese Milk Vetch Application Rates

Agronomy
Soluble organic nitrogen (SON) plays a critical role in soil nitrogen cycling, yet the effects of Chinese milk vetch (CMV) application on the composition of SON within paddy soil profiles remains poorly understood.
Jing Yang, Le Xiang, Fenghua Ding, Hongyu Huang, Biqing Zhou, Chengsen Zhao, Shihe Xing, Shuxin Liu   +7 more
doaj   +1 more source

Activities of peroxidase (soluble and cell wall bound) and of other H2O2 scavenging enzymes are markers of the flower bud development stage in lemon

Journal of Applied Botany and Food Quality, 2014
Specific activities of H2O2 scavenging enzymes, soluble peroxidase (G-POD), catalase (CAT) and ascorbate peroxidase (APX), and cell wall bound (CWB) G-POD, have been characterized in flower buds and leaves in potted lemon trees (Citrus limon L.
Faouzi Kasraoui, Isabelle Duquesnoy, Peter Winterton, Thierry Lamaze   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source