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Soluble ST2: A complex and diverse role in several diseases
Clinica Chimica Acta, 2020The Suppression of Tumorigenicity 2 protein (ST2) is a member of the interleukin (IL) 1 receptor family with transmembrane (ST2L) and soluble (sST2) isoforms that are (over)expressed in several cells in different conditions and following various triggers (e.g. inflammation, stress).
Evgenija Homsak, Damien Gruson
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Soluble ST2 Is a Marker for Acute Cardiac Allograft Rejection
The Annals of Thoracic Surgery, 2011Soluble ST2 (sST2), an interleukin (IL)-1 receptor family member, has a role in immunologic tolerance and has also emerged as a biomarker of cardiac stretch and remodeling. The sST2 role in heart transplantation is still unknown.From the heart transplantation population at our institution (n = 74), we selected a subset of 26 patients who had an acute ...
Domingo A, Pascual-Figal +9 more
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Pretreatment with soluble ST2 reduces warm hepatic ischemia/reperfusion injury
Biochemical and Biophysical Research Communications, 2006The interleukin-1 receptor-like protein ST2 exists in both membrane-bound (ST2L) and soluble form (sST2). ST2L has been found to play an important regulatory role in Th2-type immune response, but the function of soluble form of ST2 remains to be elucidated.
Hui, Yin +8 more
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Soluble ST2 reflects hemodynamic stress in non-ischemic heart failure
International Journal of Cardiology, 2015Elevated levels of soluble ST2 (sST2) are associated with adverse outcome in heart failure. A change in sST2 levels has also been shown to presage outcome. In vitro, ST2 expression is induced by myocardial stress and pro-inflammatory stimuli. The determinants of sST2 levels in vivo, and how they vary with clinical status over time, have not been well ...
Kaspar, Broch +7 more
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Serum-soluble ST2 and systemic sclerosis arthropathy
Clinical Rheumatology, 2022Interleukin (IL)33 and its receptor ST2 have been involved in the pathogenesis of several conditions, including arthritis. The aim of the study was to evaluate the association between IL33 or soluble ST2 (sST2) serum levels and systemic sclerosis (SSc) articular involvement.
Amalia Colalillo +2 more
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Soluble ST2 in acute pulmonary embolism
European Heart Journal, 2023Abstract Purpose ST2 is a member of the IL-1 superfamily. It consists of two components, ST2L, which is the membrane form, and sST2, which is soluble in blood. Soluble ST2 (sST2) is a cardiovascular injury–related biomarker.
M Uyanik +5 more
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Soluble ST2: a valuable prognostic marker in heart failure
Heart Failure Reviews, 2022Natriuretic peptides have been at the forefront of biomarker use in heart disease and have been universally recommended as the ideal biomarker in the setting of heart failure. Soluble ST2 is one such biomarker which has found value as a prognostic marker and can be used individually or along with natriuretic peptides in order to prognosticate patients ...
Sugeevan Savarimuthu +2 more
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Soluble ST2—Analytical Considerations
The American Journal of Cardiology, 2015Suppression of tumorigenicity 2 (ST2, also known as interleukin [IL]-1 receptor-like-1) is an IL-1 receptor family member with transmembrane (ST2L) and soluble isoforms (sST2). ST2L is a membrane-bound receptor, and IL-33 is the functional ligand for ST2L.
Thomas, Mueller, Allan S, Jaffe
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Clinica Chimica Acta, 2015
In addition to routine clinical laboratory tests (including natriuretic peptides and cardiac troponins), other biomarkers are gaining attention for their utility in heart failure (HF) management. Among them, soluble ST2 (sST2) a novel biomarker integrating inflammation, fibrosis, and cardiac stress has been included in the 2013 ACCF/AHA guideline for ...
Benjamin, Dieplinger, Thomas, Mueller
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In addition to routine clinical laboratory tests (including natriuretic peptides and cardiac troponins), other biomarkers are gaining attention for their utility in heart failure (HF) management. Among them, soluble ST2 (sST2) a novel biomarker integrating inflammation, fibrosis, and cardiac stress has been included in the 2013 ACCF/AHA guideline for ...
Benjamin, Dieplinger, Thomas, Mueller
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Soluble ST2 Testing in the General Population
The American Journal of Cardiology, 2015ST2 is a member of the interleukin (IL)-1 receptor family biomarker, and circulating soluble ST2 concentrations are believed to reflect cardiovascular stress. Recent studies have demonstrated soluble ST2 to be a strong predictor of cardiovascular outcomes in community-based populations free of cardiovascular disease.
Jennifer E, Ho +3 more
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