Results 91 to 100 of about 175 (174)

Solute carrier family 12 potassium-chloride transporter member 2 ( SLC12A2 ; NKCC1 )-based markers for schizophrenia [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Solute carrier family 12 potassium-chloride transporter member 2 (SLC12A2, NKCC1); p75 neurotrophin receptor (p75 NTR) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Remimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation

European Journal of Medical Research
Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical conditions with significant global health burdens. Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, has ...
Ruohan Li, Lingzhi Qin, Jiajia Ren, Guorong Deng, Chuchu Zhang, Jiamei Li, Jingjing Zhang, Ya Gao, Gang Wang   +8 more
doaj   +1 more source

Eye-acupuncture ameliorates ferroptosis of cerebral neuronal cells in CIRI rats by up-regulating System xc（-）-GSH-GPX4 antioxidant functional axis activities

针刺研究
ObjectiveTo observe the effect of eye-acupuncture on the antioxidant function axis： System xc（-）-glutathione-glutathione peroxidase 4 （System xc［-］-GSH-GPX4） in the cortical tissue of ischemic penumbra of acute cerebral ischemia-reperfusion injury （CIRI）
CAO Ya-rong, MA Xian-de, FAN Cheng-cheng, ZHANG Xin-yu, WANG Ao, WANG Sheng-peng, SUN Meng-yue, WANG Zhe, ZHANG Wei   +8 more
doaj  

Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus

Medicine Advances, EarlyView.
Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu, Yuan Tian, Hongbin Zhu, Bing Peng, Chunheng Mo   +4 more
wiley   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, EarlyView.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source