Results 141 to 150 of about 175 (174)
Pest Management Science, Volume 82, Issue 7, Page 6842-6863, July 2026.A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos +1 more
wiley +1 more source
Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias +7 more
wiley +1 more source
Journal of Agronomy and Crop Science, Volume 212, Issue 4, July 2026.ABSTRACT Waterlogging and salinity stresses significantly affect crop productivity and often coincide in nature. While adaptive responses to each of the individual stresses have been studied in detail, the traits conferring tolerance to combined stresses (and thus the most appropriate targets for breeding) remain poorly understood. In the present work,
Md. Hasanuzzaman +3 more
wiley +1 more source
Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs
Journal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 560-580, July 2026.ABSTRACT Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits.
Guilherme Oselame +10 more
wiley +1 more source
Provenance legacies override species effects in shaping oak rhizosphere microbiomes and metabolomes
New Phytologist, Volume 251, Issue 1, Page 488-504, July 2026.Graphical representation of experimental setup. Quercus spp. seeds were collected at two origins: upper Rhine basin (URB) and north German lowland (NGL). Summary As climate change drives more frequent drought‐heat extremes, selecting drought‐tolerant trees is crucial for future forest resilience. However, the role of tree–microbial associations remains
Sebastian Bibinger +9 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Microengineered Gradient Hydrogels for Mechanobiology
Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul +12 more
wiley +1 more source
Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy
Advanced Science, Volume 13, Issue 31, 4 June 2026.Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao +12 more
wiley +1 more source