Results 81 to 90 of about 1,811,375 (268)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Survey on Challenges Faced by Inactive Cooperative Projects in Sistan & Baluchistan Province [PDF]
تعاون و کشاورزی, 2010 This study is a survey on the challenges which inactive cooperative projects face in Sistan and Baluchistan. It proposes the most effective solutions possible to activate these projects. The research method is based on descriptive.
A.R Karbasi, M Yaghoobi, SH Shahabi
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
New aid architecture and resilience building around the Syria crisis
Forced Migration Review, 2016 The international community has been piloting an integrated humanitarian, development and government response to the crisis in the region of Syria.
Gustavo Gonzalez
doaj
Developing Improvement Solutions for Evaluation System of the Iranian Maternal Health Program: A Qualitative Study [PDF]
Taṣvīr-i salāmat, 2018 Background and Objectives: Maternal health program is one of main domains of the primary health care worldwide. Considering the identified problems in evaluation system of the Iranian maternal health program, this study was conducted to develop ...
Rozita Firooznia +3 more
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A new approach to old problems: the Solutions Alliance
Forced Migration Review, 2016 Over the last three years, the Solutions Alliance has gradually emerged as a multi-stakeholder initiative to overcome the so-called humanitarian-development divide.
Alexander Betts
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source