Results 71 to 80 of about 3,531,259 (296)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Karakterisasi Subgrup Sylow Solvable Dari Grup Poin Senyawa Fosfor Pentaklorida
Setiap molekul atau senyawa kimia memiliki operasi simetri yang mendeskripsikan keseluruhan karakter dari molekul tersebut. Himpunan dari semua operasi simetri yang berlaku pada suatu senyawa akan membentuk suatu grup.
Ema Carnia Carnia +2 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
During the 1970s a series of impressive papers by Razmyslov settled the problem of the solvability of the Burnside variety \(B_ k\), that is, the variety of groups satisfying the law \(x^ k=1\). It has long been known that for \(k=2,3,6\) the groups in \(B_ k\) are solvable of length (at most) 1,2,3 respectively. Razmyslov exhibited non-solvable groups
openaire +2 more sources
Classification of solvable Leibniz algebras with null-filiform nilradical [PDF]
In this article we classify solvable Leibniz algebras whose nilradical is a null-filiform algebra. We extend the obtained classification to the case when the solvable Leibniz algebra is decomposed as a direct sum of its nilradical, which is a direct sum ...
J. Casas +3 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The relation between college students’ academic mindsets and their persistence during math problem solving [PDF]
The present study examined the extent to which college students’ academic mindsets predicted their persistence when solving challenging math problems.
Shen, Chen +2 more
doaj +1 more source
Classification of solvable Leibniz algebras with naturally graded filiform nilradical [PDF]
In this paper we show that the method for describing solvable Lie algebras with given nilradical by means of non-nilpotent outer derivations of the nilradical is also applicable to the case of Leibniz algebras.
J. Casas +3 more
semanticscholar +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source

