Results 91 to 100 of about 4,153,672 (273)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The theory behind solvability of some difference equations and systems

Journal of Inequalities and Applications
Quite recently in the paper ‘Qualitative behavior of higher-order rational difference systems: positivity, asymptotic behavior, and periodicity’ (J. Inequal. Appl.
Stevo Stević
doaj   +1 more source

Hydrodynamics of local excitations after an interaction quench in 1D cold atomic gases

New Journal of Physics, 2016
We discuss the hydrodynamic approach to the study of the time evolution—induced by a quench—of local excitations in one dimension. We focus on interaction quenches: the considered protocol consists of creating a stable localized excitation propagating ...
Fabio Franchini, Manas Kulkarni, Andrea Trombettoni   +2 more
doaj   +1 more source

On a class of solvable higher-order difference equations

Filomat, 2017
Closed form formulas for well-defined solutions of the next difference equation xn = xn-2xn-k-2/xn-k(an + bnxn-2xn-k-2), n ? N0, where k ? N, (an)n?N0, (bn)n?N0, and initial values x-i, i = 1,k+2 are real numbers, are given. Long-term behavior of well-defined solutions of the equation when (an)n?N0 and (bn)n?N0 are constant sequences is ...
Stević, Stevo, Alghamdi, Mohammed A., Alotaibi, Abdullah, Elsayed, Elsayed M.   +3 more
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A New Conservative Difference Scheme for the General Rosenau-RLW Equation

Boundary Value Problems, 2010
A new conservative finite difference scheme is presented for an initial-boundary value problem of the general Rosenau-RLW equation. Existence of its difference solutions are proved by Brouwer fixed point theorem.
Zhang Tian-De, Chang Feng, Zuo Jin-Ming, Zhang Yao-Ming   +3 more
doaj  

A solvable system of difference equations [PDF]

, 2020
Summary: In this paper, we show that the system of difference equations \[x_n={\frac{ay^p_{n-1}+b(x_{n-2}y_{n-1})^{p-1}}{cy_{n-1}+dx^{p-1}_{n-2}}},\ y_n={\frac{{\alpha}x^p_{n-1}+{\beta}(y_{n-2}x_{n-1})^{p-1}}{{\gamma}x_{n-1}+{\delta}y^{p-1}_{n-2}}}, \] \(n\in \mathbb{N}_0\) where the parameters \(a, b, c, d, \alpha, \beta, \gamma, \delta, p\) and the ...
Taskara, Necati., Tollu, Durhasan T., Touafek, Nouressadat., Yazlik, Yasin.   +3 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Point Canonical Transformation versus Deformed Shape Invariance for Position-Dependent Mass Schrödinger Equations

Symmetry, Integrability and Geometry: Methods and Applications, 2009
On using the known equivalence between the presence of a position-dependent mass (PDM) in the Schrödinger equation and a deformation of the canonical commutation relations, a method based on deformed shape invariance has recently been devised for ...
Christiane Quesne
doaj   +1 more source