Results 91 to 100 of about 2,765 (249)

A New Conservative Difference Scheme for the General Rosenau-RLW Equation

Boundary Value Problems, 2010
A new conservative finite difference scheme is presented for an initial-boundary value problem of the general Rosenau-RLW equation. Existence of its difference solutions are proved by Brouwer fixed point theorem.
Zhang Tian-De, Chang Feng, Zuo Jin-Ming, Zhang Yao-Ming   +3 more
doaj  

Point Canonical Transformation versus Deformed Shape Invariance for Position-Dependent Mass Schrödinger Equations

Symmetry, Integrability and Geometry: Methods and Applications, 2009
On using the known equivalence between the presence of a position-dependent mass (PDM) in the Schrödinger equation and a deformation of the canonical commutation relations, a method based on deformed shape invariance has recently been devised for ...
Christiane Quesne
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

On the Solvability of Some Systems of Nonlinear Difference Equations

Symmetry
The aim of this paper is to find formulas for the solutions of the nonlinear system of difference equations related to symmetry Pn+1=TnTn−2−Pn−3−Tn,Tn+1=PnPn−2±Tn−3±Pn, where the initial conditions P−3,P−2,P−1,P0,T−3,T−2,T−1, and T0 are arbitrary real numbers.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A local meshless technique for recovering dual forms of time-varying sources in the nonlocal inverse heat equation

Results in Applied Mathematics
This study focuses on retrieving a time-dependent source term in the heat equation governed by two distinct nonlocal boundary conditions. The inverse problem is structured with an interior energy over-specification constraint.
Elyas Shivanian, Ahmad Jafarabadi, Mousa J. Huntul   +2 more
doaj   +1 more source

Sixteen practically solvable systems of difference equations [PDF]

Advances in Difference Equations, 2019
AbstractClosed-form formulas for general solutions to sixteen hyperbolic-cotangent-type systems of difference equations of interest are obtained, showing their practical solvability and completely solving a solvability problem for some concrete values of delays.
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Eulerian Numerical Model to Predict the Enhancement Effect of the Gravity-Driven Motion Melting Process for Latent Thermal Energy Storage

Entropy
Latent thermal energy storage (LTES) devices can efficiently store renewable energy in thermal form and guarantee a stable-temperature thermal energy supply.
Shen Tian, Bolun Tan, Yuchen Lin, Tieying Wang, Kaiyong Hu   +4 more
doaj   +1 more source