Results 81 to 90 of about 2,765 (249)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Hydrodynamics of local excitations after an interaction quench in 1D cold atomic gases

New Journal of Physics, 2016
We discuss the hydrodynamic approach to the study of the time evolution—induced by a quench—of local excitations in one dimension. We focus on interaction quenches: the considered protocol consists of creating a stable localized excitation propagating ...
Fabio Franchini, Manas Kulkarni, Andrea Trombettoni   +2 more
doaj   +1 more source

On a class of solvable higher-order difference equations

Filomat, 2017
Closed form formulas for well-defined solutions of the next difference equation xn = xn-2xn-k-2/xn-k(an + bnxn-2xn-k-2), n ? N0, where k ? N, (an)n?N0, (bn)n?N0, and initial values x-i, i = 1,k+2 are real numbers, are given. Long-term behavior of well-defined solutions of the equation when (an)n?N0 and (bn)n?N0 are constant sequences is ...
Stević, Stevo, Alghamdi, Mohammed A., Alotaibi, Abdullah, Elsayed, Elsayed M.   +3 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Inversive Difference Modules and Solvability of Systems of Linear Difference Equations

Rocky Mountain Journal of Mathematics, 2007
The author studies homological properties of inversive difference modules and applies them to the problem of solvability of a system of linear difference equations over a difference field. He proves the existence of Grothendieck's spectral sequence for the functor Ext in the category of inversive difference modules.
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The theory behind solvability of some difference equations and systems

Journal of Inequalities and Applications
Quite recently in the paper ‘Qualitative behavior of higher-order rational difference systems: positivity, asymptotic behavior, and periodicity’ (J. Inequal. Appl.
Stevo Stević
doaj   +1 more source

A solvable system of difference equations [PDF]

, 2020
Summary: In this paper, we show that the system of difference equations \[x_n={\frac{ay^p_{n-1}+b(x_{n-2}y_{n-1})^{p-1}}{cy_{n-1}+dx^{p-1}_{n-2}}},\ y_n={\frac{{\alpha}x^p_{n-1}+{\beta}(y_{n-2}x_{n-1})^{p-1}}{{\gamma}x_{n-1}+{\delta}y^{p-1}_{n-2}}}, \] \(n\in \mathbb{N}_0\) where the parameters \(a, b, c, d, \alpha, \beta, \gamma, \delta, p\) and the ...
Taskara, Necati., Tollu, Durhasan T., Touafek, Nouressadat., Yazlik, Yasin.   +3 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source