Results 81 to 90 of about 2,673 (255)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A New Conservative Difference Scheme for the General Rosenau-RLW Equation
Boundary Value Problems, 2010 A new conservative finite difference scheme is presented for an initial-boundary value problem of the general Rosenau-RLW equation. Existence of its difference solutions are proved by Brouwer fixed point theorem.
Zhang Tian-De +3 more
doaj
Symmetry, Integrability and Geometry: Methods and Applications, 2009 On using the known equivalence between the presence of a position-dependent mass (PDM) in the Schrödinger equation and a deformation of the canonical commutation relations, a method based on deformed shape invariance has recently been devised for ...
Christiane Quesne
doaj +1 more source
Nonlinear differential-difference and difference equations: integrability and exact solvability
Computers & Mathematics with Applications, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Results in Applied MathematicsThis study focuses on retrieving a time-dependent source term in the heat equation governed by two distinct nonlocal boundary conditions. The inverse problem is structured with an interior energy over-specification constraint.
Elyas Shivanian +2 more
doaj +1 more source
On a class of solvable higher-order difference equations
Filomat, 2017 Closed form formulas for well-defined solutions of the next difference equation xn = xn-2xn-k-2/xn-k(an + bnxn-2xn-k-2), n ? N0, where k ? N, (an)n?N0, (bn)n?N0, and initial values x-i, i = 1,k+2 are real numbers, are given. Long-term behavior of well-defined solutions of the equation when (an)n?N0 and (bn)n?N0 are constant sequences is ...
Stević, Stevo +3 more
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source