Results 131 to 140 of about 11,944 (302)
DELAY DIFFERENTIAL OPERATORS AND SOME SOLVABLE MODELS IN LIFE SCIENCES
, 2017 Using the methods of the spectral theory of differential operators in Hilbert spaces L-2-solvability of some models arising in mathematical biology are investigated.
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Fermions in Two Dimensions, Bosonization, and Exactly Solvable Models
, 2012 We discuss interacting fermion models in two dimensions, and, in particular, such that can be solved exactly by bosonization. One solvable model of this kind was proposed by Mattis as an effective description of fermions on a square lattice.
De Woul, Jonas,, Langmann, Edwin,
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ON MATHEMATICAL FOUNDATIONS OF COMPUTER SYSTEM OF TRAWLER OPTIMAL CONTROL FUNCTIONING. Part I
Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2006 The problem statement of trawler optimal control described by system with two degrees of freedom and Lagrange equations of second kind as equations of its movement are considered.
V.І. Musurivskiy
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
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FQHE-the solvable limit and beyond
, 2008 We consider the quantum Hall system in the torus geometry. In the limit where the torus becomes thin, the problem is exactly solvable and the hierarchy of quantum Hall states is manifest.
Karlhede, A., +4 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source