Results 151 to 160 of about 11,944 (302)
Computing Subgroups by Exhibition in Finite Solvable Groups
, 2008 We present practical algorithms to compute subgroups such as Hall systems, system normalizers, F-normalizers and F-covering subgroups in finite solvable groups.
Bettina Eick, Charles R. B. Wright
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Broken ergodicity in driven one-dimensional particle systems with short-range interaction
, 2006 We present a one-dimensional nonequilibrium model for a driven di usive system which has local interactions and slow nonconservative reaction kinetics.
Schütz, G. M., Rákos, Attila Gábor
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Interpretation of a General Model for Inventive Problems, the Generalized System of Contradictions [PDF]
, 2009 Organised by: Cranfield UniversityDesign of technical systems implies either optimisation or inventive problems resolution. Resolution tools and methods exist for each kind of problems.
Dubois, S., De Guio, R., Rasovska, I.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
First-order product-type systems of difference equations solvable in closed form
Electronic Journal of Differential Equations, 2015 We show that the first-order system of difference equations $$ z_{n+1}=\alpha z_n^aw_n^b,\quad w_{n+1}=\beta z_n^cw_n^d,\quad n\in\mathbb{N}_0, $$ where $a,b,c,d\in\mathbb{Z}$, $\alpha,\beta \in\mathbb{C}\setminus\{0\}$, $z_0, w_0\in\mathbb{C ...
Stevo Stevic
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source