Results 101 to 110 of about 153,560 (299)

The interaction between colloids in polar mixtures above Tc

, 2012
We calculate the interaction potential between two colloids immersed in an aqueous mixture containing salt near or above the critical temperature. We find an attractive interaction far from the coexistence curve due to the combination of preferential ...
Derjaguin B. V., Fisher M. E., Israelachvili J. N., Landau L. D., Marcus Y., Safran S., Sela Samin, Verwey E. J. W., Yoav Tsori   +8 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Charge distribution effects in the solution chemistry of polyatomic ions

Condensed Matter Physics, 2005
The distribution of charge within polyatomic ions determined in ab initio quantum chemical calculations is used to describe the solution chemistry of these species in more detail. Two examples are considered in this paper.
W.R.Fawcett
doaj   +1 more source

Tailoring the Variational Implicit Solvent Method for New Challenges: Biomolecular Recognition and Assembly

Frontiers in Molecular Biosciences, 2018
Predicting solvation free energies and describing the complex water behavior that plays an important role in essentially all biological processes is a major challenge from the computational standpoint.
Clarisse Gravina Ricci, Bo Li, Bo Li, Li-Tien Cheng, Joachim Dzubiella, Joachim Dzubiella, J. Andrew McCammon   +6 more
doaj   +1 more source

Joint density-functional theory for electronic structure of solvated systems

, 2007
We introduce a new form of density functional theory for the {\em ab initio} description of electronic systems in contact with a molecular liquid environment.
C. J. Cramer, David Roundy, J. K. Percus, J. Seminario, J. Tomasi, J. Tomasi, J.-L. Rivail, Jean-Francois Briere, R. Ramirez, S. A. Petrosyan, T. A. Arias   +10 more
core   +1 more source

Solvation simplified [PDF]

Química Nova, 2010
The effects of solvents on chemical phenomena is complex because there are various solute-solvent interaction mechanisms. Solvatochromism refers to the effects of solvents on the spectra of probes. The study of this phenomenon sheds light on the relative importance of the solvation mechanisms.
openaire   +4 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Molecular Density Functional Theory of Water describing Hydrophobicity at Short and Long Length Scales

, 2013
We present an extension of our recently introduced molecular density functional theory of water [G. Jeanmairet et al., J. Phys. Chem. Lett. 4, 619, 2013] to the solvation of hydrophobic solutes of various sizes, going from angstroms to nanometers.
Daniel Borgis, Evans R., Gray C. G., Guillaume Jeanmairet, Hansen J.-P., Hirata F., Lebedev V. I., Lemmon E., Maximilien Levesque   +8 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source