Results 41 to 50 of about 109,502 (302)

Calculation of solvency capital requirements for non-life underwriting risk using generalized linear models [PDF]

, 2017
The paper presents various GLM models using individual rating factors to calculate the solvency capital requirements for non-life underwriting risk in insurance.
Andrade-Silva, CEA, CEIOPS, EIOPA, Frees, GDV, IAA, Meng, Murphy, Sandström, SST   +10 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A market-consistent framework for the fair evaluation of insurance contracts under Solvency II [PDF]

, 2019
The entry into force of the Solvency II regulatory regime is pushing insurance companies in engaging into market consistence evaluation of their balance sheet, mainly with reference to financial options and guarantees embedded in life with-profit funds ...
Casalini, R., Fusai, G., Gambaro, A. M., Ghilarducci, A.   +3 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Assessment of factors affecting the solvency of property-liability insurance companies

Journal of Innovations and Sustainability
Purpose. This study aims to determine the effect of company size, investment return ratio, own-retention ratio and underwriting results on both the solvency ratio based on technical provisions (YTP), and the solvency ratio based on net premiums (YNP) of ...
Houssem Krache, Souad Leftaha, Tarek Chougui   +2 more
doaj   +1 more source

MODELI OCJENE KREDITNOG BONITETA PREDUZEĆA [PDF]

Zbornik Radova Ekonomskog Fakulteta u Istočnom Sarajevu, 2014
The assessment of creditworthiness is based on a detailed analysis of financial reports of the company. The most common models of creditworthiness evaluation used by the companies are the traditional method, the Altman Z-score and Kralicek quicktest.
Zvjezdana Gavrilović, Borka Popović
doaj   +1 more source

Solvency I and Solvency II in Insurance Business [PDF]

Český finanční a účetní časopis, 2006
Zaklady projektu Solventnost II už byly položeny. Struktura je budovana na třech piliřich, obsahově srovnatelnými s Basel II. Přesto se vsak některými detaily mohou od sebe lisit. Těmito třemi piliři budou financni zdroje, řidici kontroly a tržni disciplina. Jeden z konceptu, který zcela jistě bude pro pojisťovny nový, bude orientace na kapital.
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Deteriorating Financial Health of New York State's Health Centers [PDF]

, 2009
Summarizes findings on the breadth and depth of financial distress in 2001-07 in the health center sector. Highlights low levels of solvency, cash flow, and payments; discusses implications for primary care for the underserved; and makes ...

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