Results 61 to 70 of about 33,210 (297)

Assessment of factors affecting the solvency of property-liability insurance companies

Journal of Innovations and Sustainability
Purpose. This study aims to determine the effect of company size, investment return ratio, own-retention ratio and underwriting results on both the solvency ratio based on technical provisions (YTP), and the solvency ratio based on net premiums (YNP) of ...
Houssem Krache, Souad Leftaha, Tarek Chougui   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Backtesting the solvency capital requirement for longevity risk

, 2011
The determination of capital requirements represents the first Pillar of Solvency II. In this framework the Solvency Capital Requirement (SCR) is defined as the amount of capital that an insurer needs in order to remain viable in the market and maintain ...
D'Amato V., COPPOLA, MARIAROSARIA, D’Amato V.   +2 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

MODEL RISK AND DETERMINATION OF SOLVENCY CAPITAL IN THE SOLVENCY 2 FRAMEWORK [PDF]

This paper investigates the robustness of the Solvency Capital Requirement (SCR) when a log-normal reference model is slightly disturbed by the heaviness of its tail distribution.
Pierre-Emanuel Thérond, Frédéric Planchet   +1 more
core  

Risk aggregation in Solvency II: How to converge the approaches of the internal models and those of the standard formula? [PDF]

Two approaches may be considered in order to determine the Solvency II economic capital: the use of a standard formula or the use of an internal model (global or partial).
Stéphane Loisel, Laurent Devineau
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Methodological problems in solvency assessment of an insurance company [PDF]

The recent wide development and changes in insurance markets highlighted the necessity to map out the solvency analysis in a more complete framework.
Sibillo, M, Cocozza, R, Di Lorenzo, E
core  

Selecting the Right Tool for Evaluating of Solvency: the Case of Latvian Enterprises

Today the role of insolvency turns out to be crucial for the operation of business enterprises and its evaluation is one of the basic tasks of financial analysis.
Lāce, Nataļja, Koleda, Nadežda
core   +2 more sources