An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Solvent-Specific Featurization for Predicting Free Energies of Solvation through Machine Learning
, 2019 A featurization algorithm based on functional class fingerprints has been implemented within the DeepChem machine learning framework. It is based on descriptors more appropriate for solvation, taking into account intermolecular properties, and has been ...
Samuel T. Hutchinson (6476219) +3 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Solvent-Free Synthesis of a Superamphiphobic Surface by Green Chemistry
, 2019 A superamphiphobic surface having both water and oil repellence was prepared by applying a solvent-free surface coating method using liquid-CO2 in the scope of “green chemistry”.
Salih Ozbay +5 more
core +1 more source
Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst [PDF]
Journal of Sciences, Islamic Republic of Iran, 2015 A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using holmium chloride as catalyst.
S. Kakaei, H. Sid Kalal, H. Hoveidi
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Influence of solvent choice on the optimisation of a reaction–separation operation : application to a Beckmann rearrangement reaction [PDF]
, 2004 In pharmaceutical syntheses, the solvent choice generally represents a complex design step. Traditionally, this choice is operated according to criteria connected with the reaction step and without any consideration on the following separation steps. The
Elgue, Sébastien +6 more
core +1 more source
Preparation of Zirconium Phosphate Nanoparticles and Its Application in the Protection of Aldehydes [PDF]
Journal of Sciences, Islamic Republic of Iran, 2017 A novel method for the preparation of α-zirconium phosphate (ZrP) nanoparticles as an eco-friendly and recyclable heterogeneous catalyst was studied.
H. Karimi
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Active efflux systems in the solvent-tolerant bacterium Pseudomonas putida S12 [PDF]
, 2002 The aim of the research presented in this thesis was to study the molecular mechanisms of organic solvent tolerance in Pseudomonas putida S12. This bacterium is capable of growth at saturated solvent concentrations, which are lethal to normal bacteria ...
Kieboom, J.
core