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Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction [PDF]
Molecules, 2022 Multicomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013.
Zeyu Ma, Bo Wang, Lei Tao
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Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction [PDF]
MoleculesThe relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric ...
Marcos Díaz-Fernández +5 more
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Biginelli reaction catalyzed by copper nanoparticles. [PDF]
PLoS ONE, 2012 We recently reported a novel synthesis of copper nanoparticles from copper sulphate utilizing the charge-compensatory effect of ionic liquid [bmim]BF(4) and ethylene glycol. The nanoparticles were characterized and found to be stable for one year.
Manika Dewan +4 more
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Current progress in asymmetric Biginelli reaction: an update [PDF]
Molecular Diversity, 2018 The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic chemists for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones and related heterocyclic compounds. In the past decades, the asymmetric variants of this reaction have been at the
Majid M Heravi +2 more
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Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones via a Three-Component Biginelli Reaction [PDF]
Molecules, 2021 Multicomponent reactions are considered to be of increasing importance as time progresses due to the economic and environmental advantages such strategies entail.
Giovanna Bosica +3 more
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Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications [PDF]
Beilstein Journal of Organic Chemistry, 2011 Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl ...
Bruno Piqani, Wei Zhang
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Anticancer Polymers via the Biginelli Reaction [PDF]
ACS Macro Letters, 2020 We developed a polymer-drug strategy to explore anticancer polymers. A series of monomers containing groups with potential anticancer activity have been facilely prepared through the Biginelli reaction. These monomers were used to produce water-soluble polymers through convenient radical copolymerization.
Yongsan Li +6 more
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A Five-Component Biginelli-Diels-Alder Cascade Reaction [PDF]
Frontiers in Chemistry, 2018 A new multi-component condensation was discovered during the reaction of a urea, β-keto ester, and formaldehyde. In the presence of catalytic indium bromide, a Biginelli dihydropyrimidinone intermediate was further converted to a five-component ...
Taber S. Maskrey +3 more
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Modification of Starch via the Biginelli Multicomponent Reaction [PDF]
Macromolecular Rapid Communications, 2019 AbstractAn efficient and straightforward modification of starch using renewable and commercially available aromatic aldehydes (benzaldehyde, vanillin, and p‐anisaldehyde) and urea via the Biginelli multicomponent reaction is reported in this work. First, starch acetoacetate (SAA) with a degree of substitution ranging from 1.4 to 2.5, depending on the ...
Eren Esen, Michael A. R. Meier
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Microwave-Assisted Biginelli Reaction: An Old Reaction, a New Perspective [PDF]
Current Organic Synthesis, 2016 In this review, we tried to highlight the recent advances in the Biginelli reaction, leading to the synthesis of 3,4-dihydropyrimidin-2(1H)-ones, albeit only those conducted under microwave irradiation. The merits and drawbacks of these reactions are compared and discussed with those performed under conventional heating.
Mommahed Heravi, Majid +2 more
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