Results 1 to 10 of about 2,041,750 (198)

Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction. [PDF]

Molecules, 2022
Multicomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013.
Ma Z, Wang B, Tao L.
europepmc   +5 more sources

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction. [PDF]

Molecules
The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric ...
Díaz-Fernández M, Algarra M, Calvo-Losada S, Quirante JJ, Sarabia F, Pino-González MS.   +5 more
europepmc   +7 more sources

Biginelli reaction catalyzed by copper nanoparticles. [PDF]

PLoS One, 2012
We recently reported a novel synthesis of copper nanoparticles from copper sulphate utilizing the charge-compensatory effect of ionic liquid [bmim]BF(4) and ethylene glycol. The nanoparticles were characterized and found to be stable for one year.
Dewan M, Kumar A, Saxena A, De A, Mozumdar S.   +4 more
europepmc   +5 more sources

Current progress in asymmetric Biginelli reaction: an update [PDF]

Molecular Diversity, 2018
The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic chemists for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones and related heterocyclic compounds. In the past decades, the asymmetric variants of this reaction have been at the
Leyla Mohammadkhani, Razieh Moradi, Majid Momhed Heravi   +2 more
exaly   +5 more sources

Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones via a Three-Component Biginelli Reaction. [PDF]

Molecules, 2021
Multicomponent reactions are considered to be of increasing importance as time progresses due to the economic and environmental advantages such strategies entail.
Bosica G, Cachia F, De Nittis R, Mariotti N.   +3 more
europepmc   +2 more sources

Skeletal rearrangement in Biginelli reaction for the synthesis of chromenoquinoline fused spirohydantoins and their in silico cytotoxicity study. [PDF]

Sci Rep
Although Biginelli reaction is known to generate dihydropyrimidinones having wide arrays of phramacological properties, herein we report an unprecedented skeletal rearrangement in Biginelli reaction to synthesize pharmacologically versatile imidazolidine-
Mezhubeinuo, Bordoloi H, Saikia AP, Bez G.   +3 more
europepmc   +2 more sources

Functionalization of magnetic TMU-17-NH₂ MOF with organic ligands for stabilization of copper species as an efficient heterogeneous catalyst for the Biginelli reaction and the synthesis of pyran derivatives. [PDF]

Sci Rep
A novel magnetic nanocatalyst, Cu@M-TMU-17-NH₂-Gly-Met, was successfully prepared through a multi-step post-synthetic modification strategy. Initially, the TMU-17-NH₂ framework was functionalized with glyoxal, followed by immobilization of metformin to ...
Vahedian R, Alinezhad H, Kiani A.
europepmc   +2 more sources

CuI as reusable catalyst for the Biginelli reaction

Catalysis Communications, 2007
Abstract An improved protocol for the Biginelli reaction using CuI as a reusable catalyst is described. The synthesis of 3,4-dihydropyrimidin-2(1H)-ones was achieved in acetonitrile, water and under solvent-free condition. After separation of product from the reaction mixture, the mother liquor (acetonitrile or water) containing the catalyst was ...
Prodeep Phukan
exaly   +2 more sources

Magnetic core-shell Carrageenan moss/Fe₃O₄: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction. [PDF]

Chem Cent J, 2018
Magnetically recoverable polysaccharide-based metallic nanoparticles Carrageenan moss/Fe3O4 (Fe3O4@CM) was tested for the synthesis of Pyrimidinone derivatives via Biginelli reaction under reflux conditions in Water. Interestingly, Fe3O4@CM prepared from
Mohammad Zaheri H, Javanshir S, Hemmati B, Dolatkhah Z, Fardpour M.   +4 more
europepmc   +2 more sources

Defect-rich MOF-303 as a dual acid-base heterogeneous catalyst for the one-pot Biginelli synthesis of dihydropyrimidinones. [PDF]

Sci Rep
Bifunctional MOF-303 (Al) exhibits promising catalytic activity for the Biginelli reaction. However, its intrinsic microporosity may hinder reactant and product diffusion and reducing efficiency. Introducing defects is crucial for enhancing its catalytic
Shaheed N, Shaabani A.
europepmc   +2 more sources