Results 21 to 30 of about 3,427 (216)

Synthesis, Characterization, and DFT Calculation of some New Pyrimidine Derivatives and Theoretical Studies on the Corrosion Inhibition Performance [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2022
In this study, 5-benzoyl-6-phenyl-4- (4- (trifluoromethoxy) phenyl) - 1,2,3,4-tetrahydroxypyrimidine (1); 5-benzoyl-6-phenyl-4- (4- (trifluoromethoxy) phenyl) -1,2,3,4-tetrahydrothioxypyrimidine (2) and 5-benzoyl-6-phenyl-4- (3,5-dimethoxy) phenyl) -1,2 ...
Esvet Akbas, Adem Ruzgar, Akbas Cagla, Sahin Ertan   +3 more
doaj   +1 more source

Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones

Molecules, 2009
A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described.
Ji-De Wang, Chen-Jiang Liu
doaj   +1 more source

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Molecules, 2020
A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea.
Jessica Bais, Fabio Benedetti, Federico Berti, Iole Cerminara, Sara Drioli, Maria Funicello, Giorgia Regini, Mattia Vidali, Fulvia Felluga   +8 more
doaj   +1 more source

New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90. [PDF]

Chem Biol Drug Des
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Bordoni C, Elstow TZ, Brancale A, Clarkson RWE, Westwell AD.   +4 more
europepmc   +2 more sources

An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

Molecules, 2015
We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions.
Yonghong Zhang, Bin Wang, Xiaomei Zhang, Jianbin Huang, Chenjiang Liu   +4 more
doaj   +1 more source

N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis [PDF]

, 2016
Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list ...
Farmer, Thomas James, Hunt, Andrew John, Moonen, Kristof, Parker, Helen Louise, Sherwood, James Richard   +4 more
core   +1 more source

POM@MOF hybrids : synthesis and applications [PDF]

, 2020
The hybrid materials that are created by supporting or incorporating polyoxometalates (POMs) into/onto metal–organic frameworks (MOFs) have a unique set of properties.
Abednatanzi, Sara, Leus, Karen, Liu, Ying-Ya, Sun, Jiamin, Van Der Voort, Pascal   +4 more
core   +1 more source

A Five-Component Biginelli-Diels-Alder Cascade Reaction

Frontiers in Chemistry, 2018
A new multi-component condensation was discovered during the reaction of a urea, β-keto ester, and formaldehyde. In the presence of catalytic indium bromide, a Biginelli dihydropyrimidinone intermediate was further converted to a five-component ...
Taber S. Maskrey, Madeline C. Frischling, Mikhaila L. Rice, Peter Wipf   +3 more
doaj   +1 more source

High-Shear Enhancement of Biginelli Reactions in Macromolecular Viscous Media. [PDF]

Macromol Rapid Commun
Biginelli reactions are important multicomponent reactions in macromolecular chemistry. it is demonstrated that by using the vortex fluidic device (VFD) Biginelli reactions can be completed at room temperature in just 1 h. However, the critical need to understand solution viscosity as a function of macromolecular chain length to better understand ...
Bui AH, Rowlands NB, Fernando Pulle AD, Gibbs Medina SA, Rohrsheim TJ, Tuten BT.   +5 more
europepmc   +2 more sources

HBF4 Catalysed Nucleophilic Substitutions of Propargylic Alcohols [PDF]

, 2015
The activity of HBF4 (aqueous solution) as a catalyst in propargylation reactions is presented. Diverse types of nucleophiles were employed in order to form new C–O, C–N and C–C bonds in technical acetone and in air.
Barreiro, EB, Diez-Gonzalez, S, Lau, SHL, Sanz Vidal, ASV, Sheppard, TS, Tan, ET   +5 more
core   +2 more sources