Development of Styryl-Modified 3,4-Dihydropyrimidin-2(1H)-ones as Potential Antitumor Agents. [PDF]
ChemMedChemStyryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Panagoulias K +10 more
europepmc +2 more sources
STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013 The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivatives using starch sulfuric acid as an environmentally friendly biopolymer-based solid acid catalyst from aldehydes, β-keto esters and urea/ thiourea without solvent is described ...
Ramin Rezaei +3 more
doaj +2 more sources
Ultrasound-assisted one-pot synthesis of dihydropyrimid-2-one/thiones catalyzed by zirconyl chloride hexahydrate [PDF]
مجلة التربية والعلم, 2013 Different substituted dihydropyrimidinones and dihydropyrimidin thiones were generated from the Biginelli reaction between aromatic aldehydes, 1,3-dicarbonyl and urea or thiourea under ultrasonic irradiation method.
Omar Yahya, Badie Ahmed, Imad Thanoon
doaj +1 more source
Polymer-Supported Dioxidovanadium(V) Complex-Based Heterogeneous Catalyst for Multicomponent Biginelli Reaction Producing Biologically Active 3,4-Dihydropyrimidin-2-(1H)-ones [PDF]
, 2023 Dioxidovanadium(V) complex [VVO2(sal-aebmz)] (1) (where Hsal-aebmz = Schiff base derived from the condensation of salicylaldehyde and 2-aminoethylbenzimidazole) has been immobilized on chloromethylated polystyrene (PS-Cl) cross-linked with divinylbenzene
Kaushik Ghosh +3 more
core +1 more source
Double catalytic effect of (PhNH3)2CuCl4 in a novel, highly efficient synthesis of 2-oxo and thioxo-1,2,3,4-tetra-hydopyrimidines [PDF]
Journal of the Serbian Chemical Society, 2015 An innovative route for the construction of 2-oxo and thioxo-1,2,3,4-tetrahydropyrimidines was delineated through a multicomponent reaction under Biginelli conditions, starting from different aromatic aldehydes, β-ketoesters and urea or thiourea.
Janković Nenad +2 more
doaj +1 more source
Highly Enantioselective Organocatalytic Biginelli and Biginelli-Like Condensations: Reversal of the Stereochemistry by Tuning the 3,3′-Disubstituents of Phosphoric Acids [PDF]
, 2016 Organocatalytic enantioselective Biginelli and Biginelli-like reactions by chiral phosphoric acids derived from 3,3′-disubstituted binaphthols have been investigated.
Xiao-Hua Chen (1336080) +5 more
core +7 more sources
Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions
Pharmaceuticals, 2022 The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Francisco Sánchez-Sancho +6 more
doaj +1 more source
Highly Enantioselective Organocatalytic Biginelli Reaction [PDF]
Journal of the American Chemical Society, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiao-Hua, Chen +4 more
openaire +2 more sources
Construction of Isocytosine Scaffolds via DNA-Compatible Biginelli-like Reaction [PDF]
, 2023 Herein we report a DNA-compatible Biginelli reaction to construct isocytosine scaffolds. This reaction utilizes a one-pot reaction of DNA-conjugated guanidines with aldehydes and methyl cyanoacetates to give isocytosine derivatives, and the method is ...
Yizhou Wu +9 more
core +1 more source
N-Donor ligand activation of titanocene for the Biginelli reaction via the imine mechanism. [PDF]
RSC Adv, 2018 Stable titanocene dichloride (Cp2TiCl2) was activated by the N-donor ligand urea to form [(MeO)2Ti(NHCONH2)]+, which catalyzed the Biginelli reaction to produce 3,4-dihydropyrimidin-2-(1H)-ones.
Zheng S +7 more
europepmc +2 more sources