Results 21 to 30 of about 2,041,750 (198)

Ultrasound-assisted one-pot synthesis of dihydropyrimid-2-one/thiones catalyzed by zirconyl chloride hexahydrate [PDF]

مجلة التربية والعلم, 2013
Different substituted dihydropyrimidinones and  dihydropyrimidin thiones were generated from the Biginelli reaction between aromatic aldehydes, 1,3-dicarbonyl and urea or thiourea under ultrasonic irradiation method.
Omar Yahya, Badie Ahmed, Imad Thanoon
doaj   +1 more source

STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013
The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivatives using starch sulfuric acid as an environmentally friendly biopolymer-based solid acid catalyst from aldehydes, β-keto esters and urea/ thiourea without solvent is described ...
Ramin Rezaei, Sara Malek, Mohammad Reza Sheikhi, Mohammad Kazem Mohammadi   +3 more
doaj   +1 more source

Double catalytic effect of (PhNH3)2CuCl4 in a novel, highly efficient synthesis of 2-oxo and thioxo-1,2,3,4-tetra-hydopyrimidines [PDF]

Journal of the Serbian Chemical Society, 2015
An innovative route for the construction of 2-oxo and thioxo-1,2,3,4-tetrahydropyrimidines was delineated through a multicomponent reaction under Biginelli conditions, starting from different aromatic aldehydes, β-ketoesters and urea or thiourea.
Janković Nenad, Bugarčić Zorica, Marković Svetlana   +2 more
doaj   +1 more source

Highly Enantioselective Organocatalytic Biginelli Reaction [PDF]

Journal of the American Chemical Society, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiao-Hua, Chen, Xiao-Ying, Xu, Hua, Liu, Lin-Feng, Cun, Liu-Zhu, Gong   +4 more
openaire   +2 more sources

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions

Pharmaceuticals, 2022
The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Francisco Sánchez-Sancho, Marcos Escolano, Daniel Gaviña, Aurelio G. Csáky, María Sánchez-Roselló, Santiago Díaz-Oltra, Carlos del Pozo   +6 more
doaj   +1 more source

Concise Synthesis of Guanidine-Containing Heterocycles Using the Biginelli Reaction

, 2016
Two general methods for the synthesis of 2-imino-5-carboxy-3,4-dihydropyrimidines were developed using the three-component Biginelli reaction. The first method utilizes pyrazole carboxamidine, a β-ketoester, and an aldehyde in an initial Biginelli ...
Larry E. Overman (1264596), Bradley L. Nilsson (1421248)   +1 more
core   +3 more sources

Development of Styryl-Modified 3,4-Dihydropyrimidin-2(1H)-ones as Potential Antitumor Agents. [PDF]

ChemMedChem
Styryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Panagoulias K, Kim W, Ozdemir M, Turan B, Mardinoglu A, Turkez H, Trisciuzzi D, Nicolotti O, Di Stefano A, Vassiliou S, Cacciatore I.   +10 more
europepmc   +2 more sources

Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones

Molecules, 2009
A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described.
Ji-De Wang, Chen-Jiang Liu
doaj   +1 more source

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Molecules, 2020
A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea.
Jessica Bais, Fabio Benedetti, Federico Berti, Iole Cerminara, Sara Drioli, Maria Funicello, Giorgia Regini, Mattia Vidali, Fulvia Felluga   +8 more
doaj   +1 more source

Synthesis, Characterization, and DFT Calculation of some New Pyrimidine Derivatives and Theoretical Studies on the Corrosion Inhibition Performance [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2022
In this study, 5-benzoyl-6-phenyl-4- (4- (trifluoromethoxy) phenyl) - 1,2,3,4-tetrahydroxypyrimidine (1); 5-benzoyl-6-phenyl-4- (4- (trifluoromethoxy) phenyl) -1,2,3,4-tetrahydrothioxypyrimidine (2) and 5-benzoyl-6-phenyl-4- (3,5-dimethoxy) phenyl) -1,2 ...
Esvet Akbas, Adem Ruzgar, Akbas Cagla, Sahin Ertan   +3 more
doaj   +1 more source