Bulletin of Chemical Reaction Engineering & Catalysis, 2020 A one-pot three-component synthesis of dihydropyrimidinones (DHPMs) via Biginelli reaction was carried out at 100 °C using benzaldehyde, ethyl acetoacetate and urea as reactants, in the presence of ethanol and free solvent, in heterogeneous catalytic ...
Ouzna Kheffache +3 more
doaj +1 more source
Lanthanum triflate triggered synthesis of tetrahydroquinazolinone derivatives of N-allyl quinolone and their biological assessment [PDF]
, 2012 A series of 24 derivatives of tetrahydroquinazolinone has been synthesized by one-pot cyclocondensation reaction of N-allyl quinolones, cyclic β-diketones and (thio)urea/N-phenylthiourea in presence of lanthanum triflate catalyst.
Jardosh Hardik H., Patel Manish P.
core +1 more source
Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Molbank, 2018 The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets.
Itamar Luís Gonçalves +7 more
doaj +1 more source
The Scientific World Journal, 2012 Various Biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent-free, and eco-friendly conditions in a one-pot reaction of 1,3-dicarbonyl compounds, aldehydes, and urea/thiourea/acetyl thiourea ...
Harshita Sachdeva, Diksha Dwivedi
doaj +1 more source
A mini-review on Biginelli adducts with notable pharmacological properties
Journal of Advanced Research, 2015 Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities.
Ângelo de Fátima +6 more
doaj +1 more source
Synthesis of some new derivatives of thiazolopyrimidines and hydrolysis of its arylidene derivative [PDF]
, 2015 A new ammonium acetate-assisted, convenient and efficient procedure for the synthesis of arylidene derivatives of thiazolopyrimidine is described. The main advantages of this protocol is that it is economical, short reaction time, commonly available ...
Imtiyaz Ahmed, M. K. +2 more
core +3 more sources
Modification of Starch via the Biginelli Multicomponent Reaction [PDF]
Macromolecular Rapid Communications, 2019 AbstractAn efficient and straightforward modification of starch using renewable and commercially available aromatic aldehydes (benzaldehyde, vanillin, and p‐anisaldehyde) and urea via the Biginelli multicomponent reaction is reported in this work. First, starch acetoacetate (SAA) with a degree of substitution ranging from 1.4 to 2.5, depending on the ...
Eren Esen, Michael A. R. Meier
openaire +4 more sources
Synthesis and Crystal Structure Analysis of Ethyl-4-(4-Acetoxy-Phenyl)-3-Acetyl-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylate [PDF]
, 2012 4-(4-Acetoxy-phenyl)-3-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (2) was synthesized by a two step reaction process. Preliminary spectroscopic analysis was done by IR, 1HNMR and elemental analysis.
Honnappa Nagarajaiah, . +1 more
core +1 more source
Results in Chemistry, 2022 An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed.
Sourav Handique, Priyanka Sharma
doaj +1 more source
Bis-bromine-1,4-diazabicyclo[2.2.2]octane Complex (DABCO-Br2): An Efficient and Versatile Reagent for Preparation of Dihydropyrimidinones as a New Protocol for the Biginelli Reaction [PDF]
شیمی کاربردی روز, 2011 A simple and efficient method for the one-pot Biginelli condensation reaction of aldehydes, β-dicarbonyl compounds and urea or thiourea employing tetrameric DABCO-bromine as a novel catalyst is described.
Gholam Hossein Mahdavinia +3 more
doaj +1 more source